Our study validated the traditional use of ginger in respiratory disorders and suggests that ginger reduces allergic airway inflammation, possibly by the suppression of Th2-mediated immune response.
Objectives: To evaluate the effect of Vitamin D supplementation on proteinuria in type 2 Diabetes Mellitus patients in Chinese population. Materials and Methods: The design of this study was Quasi-experimental study design and the duration of this study was from December 2021 to June 2022. This study was conducted in the Department of medicine, in DHQ Hospital Faisalabad. Totally 30 patients who were suffering from type 2 diabetic mellitus disease were enrolled. Vitamin D levels Proteinuria, HbA1c and FBS level was evaluated. Oral Vitamin D 50,000 IU weekly dose was given to Patients with Vit D deficiency for 8 weeks. At the end of 8 week the Vitamin D levels, FBS, HbA1c and Albumin level was evaluated again. All the demographic details and study results were recorded on a predesigned data collection proforma. Results: Out of total 30 patients, 11 were male and 19 were female with mean age of 34.73±9.14 years. The most common age group was 41-50 years in which 36.7%, followed by age group of 31-40 years in which 33.3% and 30.0% patients were in age group of 41-50 years. The statistical difference between Pre-intervention and post-intervention was calculated, and p-value was significant. In our study the Vit D level increases while proteinuria decreases. Practical Implication: In diabetic patients its deficiency lead to a number of serious condition such as ischemic heart disease, CKD and Diabetic nephropathy. Vit D play its role in the inhibition of the renin-angiotensin system. It also have a protective role in the renal by preventing of glomerulosclerosis and anti-proteinuric effect. Conclusion: Vitamin D supplementation is helpful in increasing Vit D level in T2DM patients. And also helpful in decreasing proteinuria. This means that correction of Vit D level can decrease proteinuria. Keywords: Vitamin D, Proteinuria, Type 2 Diabetes Mellitus, Albumin Level, Proteinuria, Threatening Disorder.
Background: There is scarcity of published information about doctors' knowledge, attitude and adherence with hypertension guidelines from Pakistan. Objectives: To evaluate doctors' knowledge, attitude and objective adherence with the recommendations of Clinical Practice Guidelines (CPG) developed by American Society of Hypertension/International Society of Hypertension. Methods: This cross-sectional questionnaire-based study included 95 doctors from various health care facilities in Quetta, Baluchistan to evaluate doctors' knowledge of and attitude towards guidelines. Physicians' endearment with ASH/ISH (2014) guidelines was evaluated by the prescriptions they wrote to 1900 hypertensive individuals (20 prescriptions of each enrolled doctor). Data was analysed using SPSS 20. Results: 58.9% doctors had sufficient knowledge of guidelines. Doctors' with specialization and consultants, doctors of age >35 years and who were in clinical practice for >5 years had significantly (p-value<0.05) greater knowledge and more guidelines adherent practices than their counterparts. There was a significant association between doctors' knowledge and practice scores.(rs=0.758, p-value <0.001). Overall, doctors had positive attitudes towards guidelines. A total of 1385 (72.9%) prescriptions were judged guidelines adherent. In multivariate analysis, guidelines adherence had statistically significant positive association with the presence of any comorbidity (OR=2.804, p-value<0.001), heart failure (OR=5.101, p-value<0.001), chronic kidney disease (OR=2.384, p-value<0.001) and benign prostatic hyperplasia (OR=3.137, p-value=0.009) and negative association with diabetes mellitus (OR=0.265, p-value<0.001). Conclusion: Only 58.9% doctors were adequately aware of guidelines recommendations. A fair number of patients (72.9%) received guidelines adherent prescriptions. Doctors' poor knowledge of guidelines preferred antihypertensive agents in diabetic hypertensive patients reflected in their practices.
Objective: To evaluate the pain-relieving effects of duloxetine vs those of amitriptyline in the treatment of diabetic neuropathy. Methodology: In this randomized trial control, 150 cases of diabetic neuropathy by using convenient sampling technique from Medical Department of Madinah Teaching Hospital, Faisalabad were enrolled and divided in 2 equal groups randomly. Group A was assigned to (Duloxetine) and B assigned to (Amitriptyline). Patients received the trial drug in the morning with water for 6 weeks. Group A got 60 mg of Duloxetine and Group B 75 mg of amitriptyline. VAS pain rating. Patient consultations included a diary card. Patients recorded daily improvements on a visual analogue scale for the first three weeks. We administered three weeks of medicine and arranged an examination in week 6. When pain levels were 50% lower than baseline, we rated them as reduced. Patients were phoned. Results: The mean age was 46.19+6.39 years. 41(54.67%) of Group-A and 39(52%) of Group-B were male, whereas 34(45.33%) and 36(48%) were female. Both groups' mean VAS pain ratings were 1.48+0.50; p = 0.746 shows no difference. Group-A (0.48+0.50) and Group-B (0.92+0.69) vary significantly (p=0.0001). Group-A (52%) and Group-B (28%) were effectively treated after 6 weeks, p=0.002. Conclusion: Our research shows that duloxetine is superior to amitriptyline for the management of diabetic neuropathy, especially in terms of minimising the frequency with which patients report experiencing pain. Keywords: Diabetic neuropathy, management, duloxetine, amitriptyline, efficacy
Introduction: Anaemia is a condition in which the number of red blood cells is insufficient to meet physiologic needs; it is caused by many conditions, particularly iron deficiency. Objectives: The main objective of the study is to find the effectiveness of vitamin C for iron supplementation in patients with iron deficiency anemia. Material and methods: This cross sectional study was conducted in Chandka Medical College Hospital Larkana during February, 20220 to March 2021 with the permission of ethical committee of hospital. Data were collected from 100 patients suffering from iron deficiency anemia (IDA). Participants were selected through randomly sampling technique. Results: The data was collected from 100 patients and mean age was 45.67±5.81 years. The only factors which emerged as statistically significant from the adjusted logistic regression analysis model were insufficient intakes of iron (OR = 7.39; 95% CI: 1.45-37.57) and vitamin C (OR = 6.14; 95% CI: 1.34-28.27), frequent (≥2 times per week) tea consumption (OR = 0.01; 95% CI: 0.01-0.08), infrequent (≤2 times per week) red meat consumption (OR = 3.71; 95% CI: 1.01-13.61), and the possession of a personal history of IDA (OR = 6.00; 95% CI: 1.45-24.76). Conclusion: It is concluded that main risk factors in relation to contracting anemia were inadequate intakes of iron and vitamin C, frequent tea consumption, infrequent red meat consumption, and a past personal history of IDA. Keywords: Patients, Anemia, Hb, Iron
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