The Effect of Vitamin D Supplementation on Proteinuria in Type 2 Diabetes Mellitus Patients in DHQ Hospital Faisalabad

Abstract

Objectives: To evaluate the effect of Vitamin D supplementation on proteinuria in type 2 Diabetes Mellitus patients in Chinese population. Materials and Methods: The design of this study was Quasi-experimental study design and the duration of this study was from December 2021 to June 2022. This study was conducted in the Department of medicine, in DHQ Hospital Faisalabad. Totally 30 patients who were suffering from type 2 diabetic mellitus disease were enrolled. Vitamin D levels Proteinuria, HbA1c and FBS level was evaluated. Oral Vitamin D 50,000 IU weekly dose was given to Patients with Vit D deficiency for 8 weeks. At the end of 8 week the Vitamin D levels, FBS, HbA1c and Albumin level was evaluated again. All the demographic details and study results were recorded on a predesigned data collection proforma. Results: Out of total 30 patients, 11 were male and 19 were female with mean age of 34.73±9.14 years. The most common age group was 41-50 years in which 36.7%, followed by age group of 31-40 years in which 33.3% and 30.0% patients were in age group of 41-50 years. The statistical difference between Pre-intervention and post-intervention was calculated, and p-value was significant. In our study the Vit D level increases while proteinuria decreases. Practical Implication: In diabetic patients its deficiency lead to a number of serious condition such as ischemic heart disease, CKD and Diabetic nephropathy. Vit D play its role in the inhibition of the renin-angiotensin system. It also have a protective role in the renal by preventing of glomerulosclerosis and anti-proteinuric effect. Conclusion: Vitamin D supplementation is helpful in increasing Vit D level in T2DM patients. And also helpful in decreasing proteinuria. This means that correction of Vit D level can decrease proteinuria. Keywords: Vitamin D, Proteinuria, Type 2 Diabetes Mellitus, Albumin Level, Proteinuria, Threatening Disorder.