AIMS AND OBJECTIVES:To study the effectiveness of microdermabrasion with Vitamin C serum for facial melanoses, superficial rhytides and rejuvenation. MATERIALS AND METHODS: Thirty patients were included in the study. Microdermabrasion was done on the face with machine pressure of 20mm of mercury. The face was wiped with saline soaked guaze and dried. One ml of Vitamin c serum with 15% concentration applied with droplet to entire face. The procedure was repeated at an interval of 15 days for 4 sittings. Photographs were taken and compared with patient's visual satisfaction and treating dermatologist's assessment before 1 st sitting of the procedure and at the end of 4 th sitting. OBSERVATION AND RESULTS: A total of thirty patients were included in the study and followed up for a period of two months. Male to female ratio was 3:7. The age of the patients ranged between 20 years and 35 years, with majority of them in the age group of 31-35 years. Among 15 patients with postinflammatory hyperpigmentation the treatment was not effective in 6 patients and mildly effective in 9 patients. Among 9 patients with photomelanoses the treatment was not effective in 3 patients and mildly effective in 6 patients. Among 3 patients each with superficial rhytides and facial rejuvenation moderately good effectiveness of the treatment was observed in 2 patients and 1 patient with superficial rhytides and facial rejuvenation respectively. Excellent result was obtained in 1 patient and 2 patients with superficial rhytides and facial rejuvenation respectively. CONCLUSION: MDA with Vitamin C serum is effective in the management of superficial rhytides and facial rejuvenation and it is either ineffective or only mildly effective in patients with post inflammatory hyperpigmentation and photomelanoses.
Introduction: Vitiligo is a disorder of skin pigmentation that is associated with tremendous psychological impact on the affected patients. The prevalence of vitiligo range from 0.1% to 8%. Narrow Band Ultraviolet B (NBUVB) therapy has been reported to be effective and a safe tool in vitiligo. Aim: To determine the effect of NBUVB treatment on vitiligo patients and to assess the impact on Dermatology Life Quality Index (DLQI) of patients after the therapy. Materials and Methods: This was a prospective study conducted pre and post intervention (NBUVB) on all the vitiligo patients attending Dermatology Outpatient Department (OPD) at our Institute from January 2019 to June 2019. The estimated sample size was 80 patients. The patients who met the inclusion criteria underwent whole body NBUVB irradiation. The treatment was started with an initial dose of 300 mJ/cm2 in all the cases. It was administered two days per week on non consecutive days. The irradiation dose was increased by 50 mJ/cm2 on each subsequent visit until the optimal dose was obtained to have a minimal erythema in the lesion. The DLQI questionnaire designed by Finlay and Khan was used to determine the quality of life impairment in the study patients. The DLQI scoring was done twice, the first scoring at the start of therapy and the second scoring at the end of therapy. The data was analysed using Statistical Package for the Social Sciences (SPSS) 20.0 version software for determining statistical significance. Chi-square test, Fisher-exact test and odds ratio were used to check for the associated factors, p-value <0.05 was considered to be statistically significant. Results: A total of 79 patients were included in the study. Age ranged from 18 to 72 years, with a mean age of 43.2±15.14 years. The sex distribution among study patients was almost equal, with 39 females and 40 males. The duration of NBUVB irradiation ranged from two months to six months. The cumulative number of NBUVB irradiation sessions ranged from 14 to 48, with an average of 22.65±7.42 sessions. The grade of repigmentation in the study group was excellent in 2 (2.5%), good in 52 (65.8%), average in 25 (31.7%) and poor in none. The baseline DLQI score distribution ranged from 6 to 28, with mean score of 11.76±3.69. The end of therapy DLQI score ranged from 0-7, with mean score of 2.58±2.32. The difference between the mean baseline DLQI score and end of therapy DLQI score was statistically significant. Conclusion: The NBUVB treatment is effective on vitiligo patients in achieving repigmentation of depigmented patches. The baseline DLQI score of vitiligo patients were high, and it significantly decreased after the NBUVB therapy.
BACKGROUND Melasma is the most common facial pigmentary disorder causing cosmetic disfigurement. Treatment options are numerous with varied results. The aim of this study is to compare the therapeutic response of melasma in south Indian patients when treated by 20% trichloroacetic acid peel and 1% tretinoin yellow peel in a split-face study. MATERIALS AND METHODSAn experimental study was done on hundred patients over a period of 1 year between December 2014 and November 2015. Patients were selected as per the inclusion and exclusion criteria. The face was arbitrarily divided into right and left halves. Right half was treated with Obagi blue peel containing trichloroacetic acid 20% and left half with yellow peel containing tretinoin 0.1%. A total of 4 sittings of peel at an interval of four weeks was done for all the patients. Clinical colour photographs were taken before the start of each sitting of peel and at followup. RESULTSThere were 100 patients included in the study, 78 were females and 22 were males. Epidermal melasma accounts for 75% and mixed melasma 25%. Duration of melasma ranged from 1 month to 60 months with mean duration of 34 months. The percentage reduction of MASI score in mixed melasma was 34.6% in TCA group and 33.7% in Tretinoin group. The percentage reduction of MASI score in epidermal melasma was 72.9% and 70.2% in TCA group and Tretinoin group. CONCLUSIONThe therapeutic response of melasma to TCA peel and Tretinoin peel is similar in our study. The response to treatment was significantly better in the epidermal melasma patients when compared to mixed melasma patients with either of the peel agents.
Primary cutaneous plasmacytosis is a rare disorder. Cases have been mostly reported from Japan. Here, a rare case of cutaneous plasmacytosis with calcium deposits was reported from southern part of India. A 47-year-old male patient presented with solitary asymptomatic nodule on the left leg present for two decades. Skin biopsy showed sheets of plasma cells in mid-dermis with bony trabeculae extending upto subcutis which was unremarkable. Serum electrophoresis did not reveal any M band and Bence Jones protein was absent in urine. Radiograph of the left leg showed focal lesion with calcific areas in soft tissue shadow with probability of calcification. Novelty of the case lies in its rare clinical presentation in this population with histopathological documentation.
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