Background: Oral cancer is the sixth most common cancer in the world. P53 mutations are associated with the development of oral squamous cell carcinomas. This study is to determine the presence of p53 oncogene expression in cases of oral malignant, premalignant and benign lesions and to show association of p53 oncogene and lymph node enlargement in malignant lesion. Materials and methods:Four to five micron-thick sections of formalin fixed, paraffin embedded biopsy material from various intra-oral sites of 50 patients were collected, in the series of 50 cases, 35 oral squamous cell carcinoma, 10 dysplastic lesions and 05 hyperplastic lesions were assessed for p53 expression. The tissue sections were immunohistochemically analyzed for the expression of p53 gene.Results: Out of 50; 22/35 (63%) cases of squamous cell carcinoma, 02/10 (20%) cases of dysplasia (20%), were positive for p53. Five hyperplastic lesions were negative for p53. The P53 protein was not identified in benign lesion. Conclusion:Results indicate that p53 over-expression is seen in oral squamous cell carcinomas. It is a significant marker of carcinogenesis and can be considered as an important marker for clinical evaluation, diagnosis as well as prognosis of disease.

Background: This study carried out in the Department of Surgery, MGM Medical College & M.Y.Hospital Indore both retrospectively and prospectively in patients with Blunt abdominal trauma. Result: 35 pateints out of 250 patients i.e.14% of patients with BAT came to hospital with feature of shock was considered as B.P. below 90mm of Hg. Maximun numbers of patients (88) were presented with P/A Guarding, tenderness localised at site of BAT i.e 35.2%51 patients out of 250 patients i.e 20.4% presented with head injury and with neurological sign and symptoms like unconciouness, unequal pupil, vomiting etc. There only 50 patients i.e 20% which are presented with respiratory distress as associated complaints. 76 patients i.e 30.4% of BAT presented as pain in abdomen and localised tenderness on clinical examination. Majority of the BAT were accidental in nature comprising 154 cases i.e. 61.6%. Second common injury are fall from height comprises 45 cases i.e. 18% and least common are assault by hard and blunt object and falling hard and blunt object over body comprises 18-18 cases i.e. 7.2 respectively%. In retrospective group accidental cases were 49 i.e. 61.25% in prospective groups accidental cases were 105 i.e. 61.765%. In retrospective group falling hard and blunt object over body comprises 13, cases i.e. 7.6%. In prospective groups assault by hard and blunt object comprises 5 cases i.e. 6.25%. Conclusion:Incidence of blunt abdominal trauma can be reduced by improving the social morale of people especially the younger generation by providing Good education, Preventing Alcohol Abuse, Proper law enforcement and some form of penalty regarding proper vehicle driving. 35 pateints out of 250 patients i.e.14% of patients with BAT came to hospital with feature of shock was considered as B.P. below 90mm of Hg. The BAT were accidental in nature comprising 154 cases i.e. 61.6%. Second common injuries are fall from height comprises 45 cases i.e. 18%.

We report our experience with retroperitoneoscopic pyelolithotomy for renal pelvis stone disease (>1.5 cm) and comparisons were made with reference to type of renal pelvis, intrarenal or extrarenal. MATERIAL AND METHODS: Sixty patients underwent retroperitoneoscopic pyelolithotomy for large renal pelvis stone disease (>1.5 cm) in our hospital between 2008 and 2012.The patients in both the groups (Intrarenal or Extrarenal) were assessed preoperatively and intra operatively. Variables such as operative time, need for DJ stent placement either pre op/intra op / post op, drain placement, drain removal, post op mean hospital stay were compared between the two groups. We excluded patients with history of renal surgery. RESULTS: Conversion was required in five cases (8.3%). None of the patients landed in significant medical post op complications. In total DJ stent was inserted in 26 patients (43.3%), pre operatively, in eight patients and intra-operatively, in 18 patients. No patient required post op D J stent placement Average duration of surgery was 133.4 mins. Mean postoperative hospital stay was 4.44 days. (Ranged from 3-8 days). CONCLUSION: Retroperitoneoscopic Pyelolithotomy is the preferred treatment modality in patients in which open surgery is contemplated. We conclude that it is better to place DJ stent either pre op or intra op since it facilitates suturing of pelvis. Drain removal was done slightly earlier in patients with intrarenal pelvis group. There was no significant difference in post-operative mean hospital stay among both the group. Conversion rate was more with intrarenal pelvis.

No abstract

Background: Obesity is a worldwide epidemic and exercise supplemented with pharmacotherapy has poor long-term results; thus, bariatric surgery is the mainstay therapy for morbid obesity. But reduction in weight and BMI after bariatric surgery is not the same and mainly depends on the type of surgery performed. Aim and objective: To study the comparative efficacy among three bariatric surgeries viz. Laparoscopic gastric imbrication (LGI), laparoscopic sleeve gastrectomy (LSG), and laparoscopic Roux-en-Y gastric bypass (LRYGB) in morbid obese patients in relation to weight loss and reduction in BMI. Study design: Prospective study. Materials and methods: Total of 40 morbid obese patients underwent different types of laparoscopic bariatric surgery and were followed for 1 year. Reduction in weight and BMI after 1 year was correlated with the type of bariatric surgery performed. Statistical analysis: Paired t-test, analysis of variance (ANOVA), Bonferroni. Results: Patients undergone LGI, LSG, and LRYGB had a preoperative mean weight/BMI of 105.33 kg/41.07 kg m −2 , 104.07 kg/42.76 kg m −2 , and 105.8 kg/43.27 kg m −2 , respectively; and postoperative mean weight/BMI after 1 year was 87.4 kg/34.08 kg m −2 , 81.07 kg/33.32 kg m −2 , and 81.2 kg/33.18 kg m −2 , respectively. On applying ANOVA and Bonferroni, LSG and LRYGB group had greater weight loss and reduction in BMI as compared to LGI group. Conclusion: LSG and LRYGB are statistically better in weight and BMI reduction in obese as compared to LGI. Although weight and BMI reduction was more in LRYGB as compared to LSG, it was not statistically significant.