Background: Oral cancer is the sixth most common cancer in the world. P53 mutations are associated with the development of oral squamous cell carcinomas. This study is to determine the presence of p53 oncogene expression in cases of oral malignant, premalignant and benign lesions and to show association of p53 oncogene and lymph node enlargement in malignant lesion. Materials and methods:Four to five micron-thick sections of formalin fixed, paraffin embedded biopsy material from various intra-oral sites of 50 patients were collected, in the series of 50 cases, 35 oral squamous cell carcinoma, 10 dysplastic lesions and 05 hyperplastic lesions were assessed for p53 expression. The tissue sections were immunohistochemically analyzed for the expression of p53 gene.Results: Out of 50; 22/35 (63%) cases of squamous cell carcinoma, 02/10 (20%) cases of dysplasia (20%), were positive for p53. Five hyperplastic lesions were negative for p53. The P53 protein was not identified in benign lesion. Conclusion:Results indicate that p53 over-expression is seen in oral squamous cell carcinomas. It is a significant marker of carcinogenesis and can be considered as an important marker for clinical evaluation, diagnosis as well as prognosis of disease.
All patients with locally unresectable pancreatic cancer should be offered chemoradiation therapy, in hopes of down staging the tumor for possible resection and achieving higher survival.
Background: Shoulder joint is an extremely mobile joint with reduced stability. Pain and discomfort due to shoulder joint instability is common cause of orthopedic referrals in young individuals. Diagnostic Arthroscopy is the gold standard in evaluation and planning of definitive repair surgeries. Recent advancements in MR technology with increased accessibility of the general population to MR facilities have enabled non-invasive detection of pathologies associated with shoulder instability. The present study was aimed at determining the diagnostic value of shoulder MRI in shoulder instability as compared to arthroscopy. Materials and Methods: MRI and subsequent arthroscopic evaluation of 182 patients with shoulder pain and instability admitted to a busy orthopedic referral center was done after performing adequate clinical examination and necessary investigations. Results: Sensitivity and specificity of MRI was 95.87% & 89.41%, for detection of Bankart's lesion, 98.24% & 93.24% respectively for Hill Sach's lesion and 86.36% & 97.37% respectively for SLAP tears. High sensitivity and specificity was also found for rotator cuff tears. Conclusion: MRI can give an adequate information with regards to the pathology involved in shoulder instability and can help provide valuable input in planning of repair surgeries and can very well help to avoid unnecessary arthroscopic procedure.
Abstract:We report a case of an eighteen month old female child, who presented with abdominal pain, swelling and failure to thrive with history of blunt trauma abdomen in road traffic accident, two months back. Ultrasonography and computed tomography scan (CT scan) whole abdomen, showed a large cystic swelling behind and inferior to liver with collection in lesser sac. External drainage was done after aspiration of cyst having volume of 1500 mL which was bile stained, with successful outcome.
The role of ultrasonography (US) as an initial screening test was evaluated in 3000 consecutive cases of blunt abdominal trauma (BAT). Seventy-three were positive for free fluid collection or organ injury. US-guided aspiration was used to rule out the hollow visceral injury in those referred to nonsurgical therapy. Sixty patients underwent laparotomy. These included 53 clinically unstable patients, three stable patients with positive US-guided aspiration for bile or intestinal contents and four who deteriorated upon conservative treatment. The remaining patients with US negative for fluid had some evidence of abdominal injury on clinical examination. Ultrasonography complemented the clinical examination. Both the sensitivity and specificity of US for the detection of free fluid were 100%. The overall sensitivity was 92% in spleen injuries, 88% in liver injuries and 100% in kidney injuries, with a positive predictive value of 96%, 100% and 100% and a specificity of 97%, 100% and 100% respectively. Retrospective correlation of US with laparotomy findings regarding free fluid showed that 50-100 mL of free fluid was minimal, 100-500 mL moderate, and above 500 ml significant. Thirteen patients completed conservative treatment with an uneventful course in the hospital. Both the US findings and the clinical condition of the patient should be considered in decision-making in BAT. Unnecessary laparotomies can be avoided when the major bleeding site is not in the abdomen and such patients can be safely observed after excluding the hollow visceral injury by US-guided aspiration. US, being rapid to perform, sensitive and easily repeatable, is quite useful as an initial screening test in BAT patients. Ann Saudi Med 1996; 16(3):300-303. Trauma. 1996; 16(3): 300-303 Blunt abdominal trauma (BAT) has always been a challenge for the treating surgeon. This situation demands quick and correct decision-making in order to both perform lifesaving procedures and to avoid unnecessary laparotomies. Clinical signs are often misleading and the routine laboratory data and conventional x-ray are often not specific. HDI El Abdullah, MA Dar, AK Shukla, The Evaluation of the Role of Ultrasonography and Ultrasound-Guided Aspiration as an Initial Screening Test in Blunt Abdominal 1,2Peritoneal lavage has been extensively used in BAT patients. Although this gives a good idea about the nature of the fluid, it does not distinguish the organs involved and has a relatively high rate of negative laparotomies. 3,4 Computerized tomography (CT) is a good diagnostic tool as far as organ delineation is concerned, but using it in an unstable patient requires shifting of the patient from the trauma bay, with continuous resuscitation in the CT room. The new generation of helical CTs are able to scan the abdomen and thorax within a short time, but are not available in our hospital. [3][4][5] Ultrasonography (US) has emerged as a valuable diagnostic tool in BAT. It has the advantage of being mobile for bedside use and gives quick information regarding free in...
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.