Conus loroisii is a marine vermivorous snail found profusely in the southern seas of India. They harbor several toxic peptide components commonly called as ‘conotoxins’. In this study, we have identified and sequenced five conotoxins using proteome based tandem mass spectrometry analysis through Data analysis 4.1 software. Among them, we found Lo959 as contryphan which is previously described. All other conotoxins Lo1702, Lo1410, Lo1385 and Lo1686 belong to M-Superfamily conotoxins and novel to C. loroisii. Lo1410 is completely novel to conotoxin research with 3 disulfides and the amino acid sequence is derived as CCSTNCAVCIPCCP. All the identified M-Superfamily conotoxins are sub categorised to mini M2 superfamily conotoxins. Lo1702 and Lo1686 possess C- terminal amidation which is the key feature in conotoxins. Moreover, we have screened the natural venom for the occurrence of toxicity in the zebrafish model and brine shrimp.
Bread is an affordable staple food available world wide. People demand for the high quality breads for consumption.Bread is considered to be a daily diet food for most of the people around the world. Foods with reduced glycemic index shows less risk of some chronic diseases like diabets and stroke. Senna auriculata a plant compound which is a potential inhibitor of diabetes. Low concentration possessed high radical scavenging activity, 90% of radicals were scavenged at lower concentrations. It further proved to have the anti-hemolytic effect. The extract inhibits the alpha amylase and alpha glycosidase activity. The bread contains large amount of digestible starch which leads to glycemic index. The foods with higher glycemic index leads to type 2 diabetes mellitus. Incorporation of Senna auriculata in bread is the effective method to produce low glycemic index foods. This study was aimed to evaluate digestability of starch and glycemic index in bread through the incorporating Senna auriculata as fortified bread sample. At 60 mins of dialysate, the concentration of resistant starch of bread sample with Senna Auriculata exhibited to be low when compared with the control. The Senna auriculata fortified bread sample is compared with the control which the regular bread based on their crust, colour, symmetry, texure, eating quality, and overall quality of the bread. Bread with 6% of extract was sensory evaluated. Bioactive components like phenolic, flavonoid found to be retained in fortified bread sample. Based on the biofunctional properties developed the evaluation is analysed at the retention time of the process. The sample has higher resistant starch and lower glycemic index. This overall invitro findings gives us a promising result that due to the lower glycemic effect the Senna auriculata fortified bread sample is situable and recommended for diabetes patients.
Consequences of missing teeth which involves impairment in esthetic and masticatory functions. Replacement of missing teeth using either removable or fixed prosthesis will require a adequate bone support. Due to various causes such as dental caries, periodontitis, trauma which leads to extraction of teeth. Naturally the alveolar bone is maintained by the presence of teeth that it retains. After extraction, the alveolar bone resorption occurs both in height and width of the residual ridge which is inevitable. In patients with insufficient bone height and width, the placement of dental implants in an ideal position is very difficult. It is necessary to restore the alveolar ridge anatomy for successfully placing implants. Various surgical techniques have been introduced to augment the lost bone and one of such technique is Tent Pole technique. KEY WORDS: Guided bone regeneration, Ridge augmentation, Tent pole technique
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