Certain specific inhibiting properties of ser-m.~ from patients treated with ragweed extract were first reported in 1935 by Cooke, Bamard, Hebald, and Stull (I). They interpreted their results as "showing the development under treatment of a peculiar blocking or inhibiting type of immune body that prevented the action of allergen on the sensitizing antibody." Adequate confirmation of these findings has been forthcoming.Subsequently, Stull, Sherman, and Cooke (2) separated aqueous serum dilutions by half-saturation with ammonium sulfate into "albumin" and "globulin" and further fractionated the latter by dialysis against distilled water into waterinsoluble "euglobulin" and water-soluble "pseudoglobulin. ''t From passive transfer tests with these fractions they concluded that both sensitizing and blocking capacities were connected with "pseudoglobulin." No confusion should result from the fact that in the present work the terms "euglobulin" and "pseudoglohulin" are applied with the different meaning of "salting-out" properties essentially in accordance with Kendall's usage (3).Recently we have continued further studies to relate, if possible, both blocking and sensitizing antibody to electrophoretically defineable serum components. It was thought that such a correlation as reported in numerous publications for some precipitating and antitoxic antibodies (4--11) might also obtain for this artificially induceable "blocking" antibody.The studies here recorded indicate to us that blocking antibody is connected in large part, if not entirely, with the gamma globulin. In the three ser-m.~ studied it could not be attributed definitely to any of the other dectrophoretic components but was found predominantly in the gamma globulin. This is quite different from the results of our pre]imln~ry report on the sensitizing antibody (12), a study of which has been continued and will be amplified in a later paper.i Different meanings are appfied by various investigators to the terms %uglobulin"and "pseudoglobulin"; a precise definition should always be given, as was done in reference 2.
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