Breath analysis is a powerful technique for detection of respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD). Nitric oxide (NO), nitrous oxide (N2O), carbon dioxide (CO2) and carbon monoxide (CO) present in breath sample acts a marker for respiratory disease. A system is proposed to design a Breath Analyser instrument. Its subsystems consist of a compact fast response laser system for analysis of multiple gases by infrared absorption. For quantitative analysis of trace gases in human breath, patient's breath sample is collected inside a gas chamber. Two ends of gas chamber are mounted with concave mirrors with special type of mirror holders which have two angle adjustment piezo actuators. Angle adjustment piezo actuators are used to compensate for any angular misalignment in order of micro radians. Third piezo actuator is used for expansion of laser resonator. Special mirror holder consists of three plates which are supported with guide pins. Mirror is mounted on tilt plate which can be rotated in vertical and horizontal direction with the help of two piezo actuators. This mirror holder structure is made of stainless steel and can be used in any type of air and vacuum environment. It is found that for linear misalignment given to any mirror of optical cavity, the angular misalignment exists and vice versa. Thus artifact elimination of laser cavity is sensitive process. With three piezo actuator based special mirror holders, a precise measurement of laser absorption can be done.
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