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Background & Objective: Nowadays, actin-binding proteins such as Villin and Gelsolin have been considered to be associated with aggressive tumors. This study mainly aims to determine the relationship between Gelsolin and Villin genes expression and metastasis of axillary lymph nodes in patients with breast cancer. Methods: The included population consisted of 40 confirmed cases of female breast cancer (including 20 patients with breast cancer along with axillary lymph node metastasis and 20 patients without axillary lymph node metastasis). Expression of Villin and Gelsolin genes was evaluated using Real-time PCR and pre-designed primers. Results: The mean expression level of Villin in groups with and without axillary lymph node metastasis was 3.33±1.35 and 0.87±0.88, respectively ( P <0.001). The mean Gelsolin expression levels in both groups (with and without axillary lymph node metastasis) were 4.13±2.40 and 1.00±0.35, respectively ( P <0.001). The significant relationships were independent of individuals’ age. Conclusion: Patients with axillary lymph node metastasis may express significant higher level of Villin and Gelsolin genes.

Background and Aim: The incidence of benign solid tumors in vulvar area is very rare. These tumors include fibromas, fibromayomas, lipoma, hemangiomas, neurofibromas and endometriomas. Lipoma is the most prevalent soft tissue mesenchymal tumor, but the incidence of this tumor in the vulva is very rare. The aim of this study was to report a rare case of vulvar lipoma in an adolescent girl. Case report: A single 16-year-old girl patient referred to gynecology clinic of Imam Khomeini hospital; in Tehran in Sep 2018 with chief complain of a growing vulvar mass from 3 years ago. In physical examination, a soft mass of 4×7 cm with regular border was detected in the medial aspect of right labia majora. There was no evidence of erythema, discharge, ulcer or tenderness. A yellow encapsulated tumor with soft consistency similar to adipose tissue was removed. Diagnosis of lipoma was confirmed by histopathological examination. Conclusion:Although vulvar lipoma is a rare tumor especially in adolescent age, complete excision and confirmation of the benign nature of this tumor by histopathological examination should be considered necessary.