A deep giant aggressive angiomyxoma of the labia majora: A case report

Ayati, Elnaz; Pesikhani, Maryam Deldar; Karamali, Maryam; Borhan, Armin; Pourali, Leila

doi:10.1016/j.ijscr.2022.107313

Cited by 4 publications

(5 citation statements)

References 15 publications

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“…The tumor size varies from 1-60 cm (9). In our case, we reported the tumor size to be approximately 10 cm in the operation field.…”

Section: Discussionmentioning

confidence: 50%

“…In deep tumors, even resection of adjacent organs like the bladder or vagina may be considered (10). There is a rubbery consistency, on the gross section of this tumor, and the gelatinous surface contains hemorrhagic points (9). Histologically, the tumor consists of stellate and spindle-shaped neoplastic cells, distinguished by a myxoid stroma.…”

Section: Discussionmentioning

confidence: 99%

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Massive aggressive angiomyxoma of ischioanal region with relapse: A case report

Naderzadeh,

Attarbashi,

Pourali

et al. 2024

IJRM

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Background: Aggressive angiomyxoma (AA) is a rare and slow-growing tumor in the pelvic and perineal regions that might develop into other perineal structures. It can present variably, ranging from a painless mass to non-specific symptoms such as dyspareunia. Due to the high relapse rate, extensive tumoral resection is reasonably required to prevent recurrences. It is also commonly confused with other conditions such as lipomas, Bartholin’s gland cysts, and hernias. Case Presentation: A 43-yr-old female diagnosed with AA 10 yr ago was evaluated as a consequence of the tumor recurrence. She presented rare manifestations of a giant and cystic pelvic mass involving pararectal and paravaginal tissue in front of the sacrum. Conclusion: Although AA is a rare and slow-growing tumor, close observation is recommended due to the high relapse rate. Furthermore, extensive tumoral resection and regular follow-up can reduce morbidity in these patients. Key words: Vulvar neoplasm, Perineum, Pelvic neoplasms, Recurrence.

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“…The tumor size varies from 1-60 cm (9). In our case, we reported the tumor size to be approximately 10 cm in the operation field.…”

Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Massive aggressive angiomyxoma of ischioanal region with relapse: A case report

Naderzadeh,

Attarbashi,

Pourali

et al. 2024

IJRM

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“…This showed no statistically signi cant differences. In recent years, numerous studies have shown that incomplete or partial resection is acceptable, especially when high operative morbidity is anticipated and preservation of fertility is an issue (7,(18)(19)(20). The combination of incomplete resection with adjuvant therapy may be an effective treatment for AA, including hormonal therapy, arterial embolization, or radiation therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Other treatment modalities like angiographic embolization can be used in adjuvant setting and in cases where surgery is a contraindication or the possibility of obtaining a negative margin is dismal during resection (7). Furthermore, angiographic embolization as an alternative approach is not typically used solely and is often used in combination with other treatments, as the tumors usually being supplied with numerous feeding vessels (19). Hormonal therapy and angioembolization appear to have signi cant bene cial effects, especially as an adjuvant to surgery or where surgery is not possible (20).…”

Section: Discussionmentioning

confidence: 99%

“…Hormonal therapy and angioembolization appear to have signi cant bene cial effects, especially as an adjuvant to surgery or where surgery is not possible (20). They may aid decrease the size of the preoperative tumor so that it can be completely removed, and can also reduce the risk of postoperative recurrence (19,20). The effects of radiotherapy and chemotherapy are con ned due to the low mitotic activity of the tumor.…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathological characteristics and prognosis analysis of Aggressive angiomyxoma: A Retrospective Study

You

Wang

et al. 2022

Preprint

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Background: Aggressive angiomyxoma is a rare, locally invasive mesenchymal neoplasm with a high recurrence rate. However, our current research on the clinical characteristics, therapeutic strategies and prognosis of aggressive angiomyxoma is limited. This study aimed to improve the management of aggressive angiomyxoma by evaluating the clinicopathological characteristics, therapeutic strategies, and prognostic factors associated with aggressive angiomyxomas. Methods: Retrospectively analyzed the medical records of patients histopathologically diagnosed with aggressive angiomyxomas from May 2005 to January 2022. Data related to clinicopathological characteristics, therapeutic strategies, and survival time were recorded and analyzed. Survival and prognosis analyses were carried out to identify variables significantly associated with the outcomes. Results: fourteen patients were included in the study with a median follow-up of 78.8 months. Univariate Cox regression analysis identified tumor margin (P=0.012) and initial treatment site (P=0.039) as associated with disease-free survival (DFS). The Kaplan-Meier survival curve showed that tumor margin had a greater effect on the prognosis of patients. Patients with positive tumor margins had a significantly lower probability of survival with DFS than those with negative margins (HR= 3.41, CI:2.73-15.74, P=0.012). Meanwhile, we found that patients who underwent surgery in other hospitals had a lower probability of survival with DFS. This difference in survival was statistically significant (HR=1.48, CI:1.09-2.50, P=0.039). To further demonstrate the results of this study, we constructed a Nomogram model. The results showed that the tumor margin and initial treatment site had the greatest effect on patient prognosis and the greatest contribution to risk score, which confirmed the results of Kaplan-Meier survival curve analysis. Conclusion: Tumor margin and initial treatment site are closely associated with prognosis in aggressive angiomyxomas. Radical resection with negative tumor margins is the first choice of treatment for aggressive angiomyxomas. Patients with aggressive angiomyxomas should go to the comprehensive authoritative hospitals to obtain definitive diagnosis and effective treatment in in earlier stage. Furthermore, Patients with aggressive angiomyxomasrequire long-term follow-up, especially within three years after surgery.

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Aggressive Angiomyxoma of the Lower Female Genital Tract: A Review of the MITO Rare Tumors Group

Dellino,

Magazzino,

Domenici

et al. 2024

Cancers

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Aggressive angiomyxoma (AAM) is a rare, locally aggressive, myxoid mesenchymal neoplasm primarily found in the pelvic and perineal regions of young adult females. It is a slow growing and locally infiltrating tumor. Preoperative diagnosis is difficult due to the rarity of these tumors and absence of characteristic signs and symptoms. The primary management is tumor excision. Incomplete excision is common because of the infiltrating nature of the neoplasm and absence of a definite capsule. Other non- surgical modalities have been employed, such as radiotherapy, embolization, GnRH analogues or other anti-estrogenic agents. Local relapses occur in 30–40% of the cases, and often appear many years (sometimes decades) after the first excision. Occasional distant metastasis has also been reported. A limited number of cases have been reported in the literature, mostly in the form of small case series or isolated case reports. Therefore, the aim of this paper by a team of experts from the MITO rare tumors group is to review clinical findings, pathologic characteristics and outcome of patients affected by this rare condition in order to be able to offer up-to-date guidance on the management of these cases.

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A deep giant aggressive angiomyxoma of the labia majora: A case report

Cited by 4 publications

References 15 publications

Massive aggressive angiomyxoma of ischioanal region with relapse: A case report

Massive aggressive angiomyxoma of ischioanal region with relapse: A case report

Clinicopathological characteristics and prognosis analysis of Aggressive angiomyxoma: A Retrospective Study

Aggressive Angiomyxoma of the Lower Female Genital Tract: A Review of the MITO Rare Tumors Group

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