Delbarre, G., B. Delbarre, and A. Ferger: Propentofylline improves the postischemic stroke index of sensitive gerbils. Drug Dev. Res. 19:99-102, 1990.The new xanthine derivative propentofylline (3-methyl-1 -[5'-oxohexyl]-7-propylxanthine), admi.nistered intraperitoneally in a dose of 25 mg/kg 10 min before ligation of the left cerebral carotid artery in "sensitive" gerbils, improves the mean stroke index significantly at 4 and 24 hr postadministration. At a dose of 10 mg/kg, propentofylline improves the mean stroke index at all examined times (4, 24, and 72 hr), but at 5 mglkg, a protective effect was obtained only after 24 hr. The mortality rate was lower in all propentofylline groups than in the control group. These results suggest that propentofylline is worth further study as a possible antistroke agent.
This study examined brain-stem auditory evoked potentials response (BAEP) changes in the gerbil after temporary occlusion of the left carotid artery. Fourteen adult gerbils were subjected to unilateral left carotid ligation for 30 min. BAEPs were registered before and 5 min after occlusion, then 5 min, 60 min, 120 min, 24 h, 7 days and 28 days after release of the clip. Waves I (cochlear nerve), III (superior olivary complex) and V (inferior colliculus) were examined. Results were analysed using paired Student's t-test. Transient ischaemia increased latencies of waves I, III and V and the changes were more severe 5 min after release of the clip. In the gerbil, BAEPs might be a suitable method to study cerebral ischaemia.
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