Propentofylline improves the postischemic stroke index of sensitive gerbils

Delbarre, Gisèle; Delbarre, B; Ferger, Arlette

doi:10.1002/ddr.430190110

Cited by 3 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Propentofylline decreased brain edema (44), intraneuronal calcium accumulation, and reactive astrocytosis ( lo), and improved the energy state of the ischemic brain as indicated by the content of energy-rich phosphates (63). The compound also reduced mortality following experimental brain ischemia and improved neurologic symptoms (7,9,45,55). The effects, again, were independent of route or time of administration.…”

Section: Ischemic Modelsmentioning

confidence: 78%

Propentofylline (HWA 285), a Neuroprotective Glial Cell Modulator: Pharmacologic Profile

Rudolphi¹,

Park

Rother³

1997

CNS Drug Reviews

View full text Add to dashboard Cite

Section: Ischemic Modelsmentioning

confidence: 78%

Propentofylline (HWA 285), a Neuroprotective Glial Cell Modulator: Pharmacologic Profile

Rudolphi¹,

Park

Rother³

1997

CNS Drug Reviews

View full text Add to dashboard Cite

“…In addition to lowering BP, amlodipine has antioxidant and anti-in ammatory properties [41,42], and enhances NO production by the endothelium [43]. Indapamide also has a number of bene ts that are independent of its diuretic effects including CCB-like vasodilatory effects [44], vasodilatory effects due to stimulation of prostaglandin I 2 [45], and antioxidative effects [46]. Both large artery stiffening and sodium sensitivity increase with age, so that drugs targeting both risk factors are likely to be of bene t in patients with ISH.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Indapamide/amlodipine Single-pill Combination in Patients With Isolated Systolic Hypertension: Post-hoc Analysis of the ARBALET Study

Кобалава¹,

Kolesnik²,

Shavarova³

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Isolated systolic hypertension (ISH) is a major cause of morbidity and mortality. This study evaluated the effectiveness of treatment with an indapamide/amlodipine single-pill combination (SPC) in outpatients with uncontrolled ISH aged over 55 years in real-life clinical practice.Methods: This was a post-hoc analysis of the subgroup of patients with ISH from ARBALET, a 3-month, multicenter, observational, open-label study conducted in Russia among patients with grade I or II hypertension who were either uncontrolled on previous antihypertensive treatment or treatment-naïve. The effectiveness of indapamide/amlodipine SPC was assessed by the change in office systolic blood pressure (SBP) and the rate of target SBP (<140 mmHg) achievement at 2 weeks, 1 month and 3 months, in four age groups: 55-59 years, 60-69 years, 70-79 years, and 80 years or older.Results: The ARBALET study recruited 2217 patients, of whom 626 had ISH and were included in this post-hoc analysis (mean age 66.1±7.8 years; 165 men [26.36%] and 461 women [73.64%]). Target SBP <140 mmHg was achieved in 43%, 75% and 93% of patients at 2 weeks, 1 and 3 months, respectively. SBP decreased from baseline by 18.8±10.5 mmHg, 27.2±10.6 mmHg and 31.8±9.9 mmHg at 2 weeks, 1 month and 3 months, respectively. In the groups of patients aged 55-59, 60-69, 70-79, and ≥80 years, SBP reductions at 3 months compared with baseline were -30.3±9.4, -32.4±9.7, -32.5±10.7, and -28.9±9.6 mmHg, respectively. Conclusion: This post-hoc analysis of the observational ARBALET study showed that indapamide/amlodipine SPC was associated with significant reductions in BP and high rates of target BP achievement in a broad age range of patients with ISH treated in routine clinical practice.Trial registration number: ISRCTN40812831

show abstract

Effect of beraprost sodium (BPS) on the postischemic neuropathological changes and stroke index after left carotid artery occlusion in gerbils

Ueno

Miyauchi

Matsuda

et al. 1994

Molecular and Chemical Neuropathology

View full text Add to dashboard Cite

We investigated the effect of beraprost sodium (BPS), a new prostacyclin analog, on behavioral and neuropathological changes induced by a 10-min occlusion of the left carotid artery in gerbils. Gerbils were treated orally with BPS (1-100 micrograms/kg) 30 min before occlusion. Pathological evaluation of neural damage in the CA1 region of the hippocampus was performed 7 d after the ischemic insults. In the symptomatic group, in which the stroke index score was > 10, symptomatic behaviors, such as head cocked, splayed out hind limb, circling, and various similar behaviors, were observed. Pathologically, almost all CA1 neurons were destroyed 7 d after ischemia in the symptomatic group. BPS improved the stroke index during ischemia and neuropathological changes 7 d later, with statistical significant improvement occurring at a dose of 100 micrograms/kg.

show abstract

Propentofylline improves the postischemic stroke index of sensitive gerbils

Cited by 3 publications

References 11 publications

Propentofylline (HWA 285), a Neuroprotective Glial Cell Modulator: Pharmacologic Profile

Propentofylline (HWA 285), a Neuroprotective Glial Cell Modulator: Pharmacologic Profile

Effectiveness of Indapamide/amlodipine Single-pill Combination in Patients With Isolated Systolic Hypertension: Post-hoc Analysis of the ARBALET Study

Effect of beraprost sodium (BPS) on the postischemic neuropathological changes and stroke index after left carotid artery occlusion in gerbils

Contact Info

Product

Resources

About