Graphical abstractA comparison of the existing isometric dorsiflexion protocol (Setting 1) and the proposed improvement of the protocol which includes the fixation of the toes in addition to fixing the ankle and foot (Setting 2) are shown. The triceps surae muscle group comprises of the lateral gastrocnemius (LG), medial gastrocnemius (MG) and soleus (SOL).
The Miniaturised Lab-on-a-Disc (miniLOAD) platform, which utilises surface acoustic waves (SAWs) to drive the rotation of thin millimeter-scale discs on which microchannels can be fabricated and hence microfluidic operations can be performed, offers the possibility of miniaturising its larger counterpart, the Lab-on-a-CD, for true portability in point-of-care applications. A significant limitation of the original miniLOAD concept, however, is that it does not allow for flexible control over the disc rotation direction and speed without manual adjustment of the disc’s position, or the use of multiple devices to alter the SAW frequency. In this work, we demonstrate the possibility of achieving such control with the use of tapered interdigitated transducers to confine a SAW beam such that the localised acoustic streaming it generates imparts a force, through hydrodynamic shear, at a specific location on the disc. Varying the torque that arises as a consequence by altering the input frequency to the transducers then allows the rotational velocity and direction of the disc to be controlled with ease. We derive a simple predictive model to illustrate the principle by which this occurs, which we find agrees well with the experimental measurements.
A model that simulates surface electromyogram (sEMG) signal of m. Tibialis Anterior has been developed and tested. This has a firing rate equation that is based on experimental findings. It also has a recruitment threshold that is based on observed statistical distribution. Importantly, it has considered both, slow and fast type which has been distinguished based on their conduction velocity. This model has assumed that the deeper unipennate half of the muscle does not contribute significantly to the potential induced on the surface of the muscle and has approximated the muscle to have parallel structure. The model was validated by comparing the simulated and the experimental sEMG signal recordings. Experiments were conducted on eight subjects who performed isometric dorsiflexion at 10, 20, 30, 50, 75, and 100% maximal voluntary contraction. Normalized root mean square and median frequency of the experimental and simulated EMG signal were computed and the slopes of the linearity with the force were statistically analyzed. The gradients were found to be similar (p>0.05) for both experimental and simulated sEMG signal, validating the proposed model.
Reduction in number of motor units (nMU) and fast fibre ratio (FFR) is associated with disease or atrophy when this is rapid. There is a need to study the effect of nMU and FFR to analyse the association with ageing and disease. This study has developed a mathematical model to investigate the relationship between nMU and FFR on surface electromyogram (sEMG) of the biceps muscles. The model has been validated by comparing the simulation outcomes with experiments comparing the sEMG of physically active younger and older cohort. The results show that there is statistically significant difference between the two groups, and the simulation studies closely model the experimental results. This model can be applied to identify the cause of muscle weakness among the elderly due to factors such as muscle dystrophy or preferential loss of type F muscle fibres.
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