Chemotherapy-induced peripheral neuropathy (CIPN) is a one of side effect in cancer patients that receive antineoplastic agent, like oxaliplatin. Orexinergic system in the hypothalamus is the one of system that modulate nociceptive and neuropathy. Because there is flavonoids such as resveratrol and andrographolide that may prevent chemotherapy induced peripheral neuropathy, this study analyzed effects of andrographolide and resveratrol treatment on PPOrx and OX1R mRNA expression in hypothalamic oxaliplatin-induced mice. Materials and Methods This study was conducted for 22 days in mice. Mice injected with oxaliplatin followed by andrographolide or resveratrol. Chemotherapy induced peripheral neuropathic pain was assessed based on withdrawal threshold, mRNA PPOrx expression, and mRNA OX1R expression. Results The results showed that intraperitoneal injection of 100mg/kg resveratrol and 20mg/kg andrographolide increased the withdrawal threshold after oxaliplatin induction. Resveratrol administration also increased the relative expression of PPOrx mRNA significantly, but not the OX1R mRNA relative expression. On the other hand, administration of andrographolide did not cause a change in the expression of PPOrx and OX1R in the hypothalamus. Conclusions Intraperitoneal injection of andrographolide and resveratrol reduces the mechanical allodynia response in oxaliplatin-induced mice significantly. The mechanism of andrographolide increases the withdrawal threshold does not via the orexinergic system, but the mechanism of resveratrol via the orexinergic system.
Sejak pandemi COVID-19, personal care product seperti masker dan hand sanitizer menjadi produk yang banyak dicari dan dibutuhkan generasi milenial. Masker digunakan untuk mencegah transmisi virus melalui droplet dari orang yang terinfeksi. Pencegahan penularan COVID-19 lebih efektif jika diiringi kebiasaan mencuci tangan dengan sabun. Namun penggunaannya kurang praktis ketika berpergian, sehingga hand sanitizer dipilih sebagai alternatif. Berdasarkan survei sosial demografi, generasi milenial cenderung lebih tidak taat dalam berperilaku menggunakan masker dan hand sanitizer dibandingkan kelompok usia lain karena mereka menganggap lebih tahan terhadap COVID-19. Penelitian ini bertujuan untuk mengetahui pengetahuan, sikap, dan perilaku penggunaan masker dan hand sanitizer pada generasi milenial. Penelitian ini merupakan penelitian cross-sectional. Pengambilan sampel dilakukan secara accidental sampling dengan kriteria inklusi laki-laki/perempuan berusia 16-30 tahun, bukan mahasiswa Fakultas Farmasi Universitas Airlangga, dan berdomisili di Jawa Timur. Penelitian dilakukan menggunakan kuesioner yang disebarkan secara daring melalui google form. Berdasarkan hasil penelitian pada 128 responden didapatkan bahwa responden memiliki pengetahuan yang baik terkait masker dan hand sanitizer namun sikap dan perilakunya masih kurang terutama dalam penggunaan hand sanitizer yang benar. Perlu dilakukan promosi kesehatan mengenai pentingnya menggunakan hand sanitizer dan masker dengan benar untuk memperbaiki sikap dan perilaku dalam mencegah penyebaran COVID-19.
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