Chemotherapy-induced peripheral neuropathy (CIPN) is a one of side effect in cancer patients that receive antineoplastic agent, like oxaliplatin. Orexinergic system in the hypothalamus is the one of system that modulate nociceptive and neuropathy. Because there is flavonoids such as resveratrol and andrographolide that may prevent chemotherapy induced peripheral neuropathy, this study analyzed effects of andrographolide and resveratrol treatment on PPOrx and OX1R mRNA expression in hypothalamic oxaliplatin-induced mice. Materials and Methods This study was conducted for 22 days in mice. Mice injected with oxaliplatin followed by andrographolide or resveratrol. Chemotherapy induced peripheral neuropathic pain was assessed based on withdrawal threshold, mRNA PPOrx expression, and mRNA OX1R expression. Results The results showed that intraperitoneal injection of 100mg/kg resveratrol and 20mg/kg andrographolide increased the withdrawal threshold after oxaliplatin induction. Resveratrol administration also increased the relative expression of PPOrx mRNA significantly, but not the OX1R mRNA relative expression. On the other hand, administration of andrographolide did not cause a change in the expression of PPOrx and OX1R in the hypothalamus. Conclusions Intraperitoneal injection of andrographolide and resveratrol reduces the mechanical allodynia response in oxaliplatin-induced mice significantly. The mechanism of andrographolide increases the withdrawal threshold does not via the orexinergic system, but the mechanism of resveratrol via the orexinergic system.
Laju pertumbuhan penduduk menjadi masalah yang sedang dihadapi pemerintah Indonesia. Upaya pemerintah dalam mengatasi masalah ini adalah melalui program Keluarga Berencana (KB) dan meningkatkan kesadaran masyarakat dalam menggunakan alat kontrasepsi. Metode kontrasepsi oral merupakan kontrasepsi yang banyak digunakan. Namun, angka kegagalan metode kontrasepsi ini tergolong tinggi. Hal ini dapat terjadi karena kurangnya pengetahuan akseptor kontrasepsi oral. Penelitian ini bertujuan untuk mengetahui profil pengetahuan wanita menikah usia subur tentang kontrasepsi oral. Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross-sectional dengan metode survei. Kriteria inklusi yaitu wanita menikah usia subur yang sedang atau pernah menggunakan kontrasepsi oral di Jawa Timur. Metode sampling yang digunakan adalah accidental sampling. Pengumpulan data dilakukan menggunakan kuesioner tervalidasi berdasarkan instrumen penelitian ini yang terdiri dari pertanyaan tentang data demografi responden (usia, pendidikan, pekerjaan) dan 15 pertanyaan terkait pengetahuan tentang kontrasepsi oral. Survei diikuti oleh 70 responden. Hasil penelitian menunjukkan 42,86% responden memiliki pengetahuan baik, 48,57% responden memiliki pengetahuan sedang, dan 8,57% responden memiliki pengetahuan kurang tentang kontrasepsi oral. Edukasi tentang kontrasepsi oral masih perlu ditingkatkan terutama mengenai faktor yang menyebabkan kegagalan metode tersebut
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