Background:
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening, aggressive syndrome. It can be primary, which involves genetic mutation with an early presentation, or secondary to infections, malignancies, etc., due to absence of immune downregulation. It is a very rare condition in newborns. Dengue is a potential virus causing HLH, but, in newborns, there are only few case reports and limited clinical literature.
Observation:
Herein, in this report, we highlight a case of neonatal HLH, triggered by perinatal dengue. The neonate manifested clinically within the first week of life, the earliest reported timeline so far in the literature.
Conclusion:
HLH should be excluded in neonates especially when multisystem involvement cannot be explained by sepsis alone.
carrying out the radiological investigation for this patient.Contributors HC, AK and RV: patient management, conception and design, draft of the manuscript, final approval of the version published, agreement to be accountable for the article and to ensure that all questions regarding the accuracy or integrity of the article are investigated and resolved. AKJ: patient management, conception and design, draft of manuscript, final approval of the version published, revising it critically for important intellectual content, agreement to be accountable for the article and to ensure that all questions regarding the accuracy or integrity of the article are investigated and resolved. He will act as guarantor for the paper.
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