Cisplatin is one of the highly consumed and effective antitumor agents whose clinical application is accompanied by nephrotoxicity adverse reaction. Also, other complications such as ototoxicity and hepatotoxicity are a matter of concern. Today, it is suggested that cisplatin‐associated toxicities are mainly induced by free radicals production, which will result in oxidative organ injury. The evidence is growing over the protective effects of antioxidants on cisplatin‐induced adverse reactions especially nephrotoxicity. The possible protective effects of vitamin E and its derivative in cisplatin‐induced nephrotoxicity and ototoxicity are reviewed here at the light of pertinent results from basic and clinical research. Administration of vitamin E alone or in combination with other antioxidant agents could cause amelioration in oxidative stress biomarkers such as decreasing the level of malondialdehyde, reducing serum urea and creatinine, and also enhancing the activities of renal antioxidant enzymes including renal catalase, glutathione‐S‐transferase, and superoxide dismutase. Although the data from most of the studies are in favors of protective effects of vitamin E against cisplatin‐induced toxicity, more clinical trials are needed to clarify the clinical importance of vitamin E administration as an antioxidant during cisplatin therapy in cancer condition.

The aim of the current study was to verify the effect of N-acetyl cysteine (NAC) supplementation on markers of oxidative stress and inflammatory response during a single session of exhaustive exercise. In a randomized placebo-controlled double-blind clinical trial, thirty healthy, untrained young males and females with a mean age of 21.33±2.39 years, weight of 59.63± 9.24 kg and height of 166.20±10.15 cm were selected and divided into 2 groups. Before starting the supplementation, blood samples were collected from all the participants. The next blood samples were collected just before the exercise started, immediately after the exhaustive exercise and after one hour of rest. Malondialdehyde (MDA), total antioxidative capacity (TAC), CRP, BMI and Vo 2 max were determined. A significant increase was observed in MDA and CRP levels during the experiment in the placebo group. But in the treated group, the concentrations remained the same throughout the experiment. The TAC levels were significantly raised in the samples collected after NAC supplementation as compared to the placebo group. No changes were observed in the time to fatigue. Results of the current study suggest that oral consumption of n-acetyl cysteine for 24 h before a single bout of an exhaustive physical exercise could significantly reduce the harmful effects of oxidative stress.