Has vitamin E any shreds of evidence in cisplatin‐induced toxicity

Abstract

Cisplatin is one of the highly consumed and effective antitumor agents whose clinical application is accompanied by nephrotoxicity adverse reaction. Also, other complications such as ototoxicity and hepatotoxicity are a matter of concern. Today, it is suggested that cisplatin‐associated toxicities are mainly induced by free radicals production, which will result in oxidative organ injury. The evidence is growing over the protective effects of antioxidants on cisplatin‐induced adverse reactions especially nephrotoxicity. The possible protective effects of vitamin E and its derivative in cisplatin‐induced nephrotoxicity and ototoxicity are reviewed here at the light of pertinent results from basic and clinical research. Administration of vitamin E alone or in combination with other antioxidant agents could cause amelioration in oxidative stress biomarkers such as decreasing the level of malondialdehyde, reducing serum urea and creatinine, and also enhancing the activities of renal antioxidant enzymes including renal catalase, glutathione‐S‐transferase, and superoxide dismutase. Although the data from most of the studies are in favors of protective effects of vitamin E against cisplatin‐induced toxicity, more clinical trials are needed to clarify the clinical importance of vitamin E administration as an antioxidant during cisplatin therapy in cancer condition.

Potential synergistic antioxidant effect of thymoquinone and vitamin E on cisplatin-induced acute nephropathy in rats

“…Reduced glutathione level decreased in cisplatin group then increased in all other treated groups to reach the level of control group in a similar way as previously described [21], whereas the increase in lipid peroxide levels in kidney tissues showed a significant increase in the cisplatin positive group as earlier reported [22]. The reactive oxygen species (ROS) such as hydrogen peroxide, superoxide anion, or hydroxyl radicals are normally generated in renal cells and immediately detoxified by endogenous antioxidant (GSH) and catalase unopposed intracellular accumulation of (ROS) leads to membrane lipid peroxidation and (DNA) damage [5,23].…”

“…Administration of Vit E alone or in combination with other antioxidant agents could cause amelioration in oxidative stress biomarkers such as decreasing the level of malondialdehyde, reducing serum urea and creatinine, and also enhancing the activities of renal antioxidant enzymes including renal catalase, glutathione-S-transferase, and superoxide dismutase [23]. Although the data from most of the studies are in favors of protective effects of Vit E against cisplatin-induced toxicity, more clinical trials are needed to clarify the clinical importance of Vit E administration as an antioxidant during cisplatin therapy in cancer condition.…”

Modulation of Oxidative Stress by Ozone Therapy in the Prevention and Treatment of Chemotherapy-Induced Toxicity: Review and Prospects

“…Today, it is suggested that cisplatin-associated toxicities are mainly induced by free radicals' production, which will result in oxidative organ injury. The evidence is growing over the protective effects of antioxidants on cisplatin-induced adverse reactions, especially, nephrotoxicity [8][9][10]. The main route for cisplatin elimination is via the kidneys, and around one out of three to four patients treated with full doses of cisplatin could develop renal dysfunction; the percentage could be higher than 50% in children.…”

Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?

“…Cell death restriction is also vital for the moderation of severe complications that accompany many other conditions, ranging from oxidative damage, obesity, inflammation, etc. to toxicity of chemotherapeutic agents [ 7 , 8 , 9 , 10 ].…”