The use of polymeric materials as drug carriers has several advantages, such as prolongation of drug action, reduction of drug side effects. In this study, we have considered the methods for the preparation of polylac-tide-co-glycolide (PLGA) polymeric nanoparticles with the anti-tuberculosis drug (ATD) isoniazid by nano-precipitation. Polymeric nanocarriers were obtained by varying individual parameters such as nature of sol-vent and non-solvent, drug/polymer ratio, and stabilizer concentration. It was determined that the average par-ticle size depends on the type of non-solvent. When alcohols were used, the average size increased in the se-quence: ethanol < isopropanol < isobutanol. The type of solvent is an important factor for the formation of nanoparticles and their final characteristics. With an increase in the drug/polymer ratio, the average size of nanoparticles also increased. The size of obtained nanoparticles varied from 93 to 869 nm. Thermogravi-metric and differential scanning calorimetry analyses were carried out to confirm the incorporation of the drug into the polymer matrix. In addition, polymer degradation and the degree of release of isoniazid from the polymeric matrix at different pH were studied. It has been shown that the nanoprecipitation method can be used not only for hydrophobic, but also for hydrophilic drugs.
The aim of this study was to create nanoparticles of human serum albumin immobilized with anti-TB drugs (rifampicin, isoniazid) using the desolvation method. Central Composite Design (CCD) was applied to study the effect of albumin, urea, L-cysteine, rifampicin and isoniazid concentration on particle size, polydispersity and loading degree of the drugs. The optimized nanoparticles were spherical in shape with an average particle size of 216.7 ± 3.7 nm and polydispersity of 0.286 ± 4.9. The loading degree of rifampicin and isoniazid in the optimized nanoparticles were 44% and 27%, respectively. The obtained nanoparticles were examined by Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC); the results showed the absence of drug–polymer interactions. The drug release from the polymer matrix was studied using dialysis membranes.
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