In this tutorial review, an effort towards presentation of a comprehensive account of the recent developments on various kinds of artemisinin derivatives including artemisinin dimers, trimers and tetramers has been made and their efficacy towards malaria parasites and different cancer cells lines was compared with that of artemisinins, and various other anti-malarial and anti-cancer drugs. It is expected that this review will provide first-hand information on artemisinin chemistry to organic/medicinal chemists, and pharmacologists working on anticancer and anti-malarial drug development.

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ABSTRACT:The living/controlled radical polymerization of stearyl methacrylate was carried out with a conventional radical initiator (2,2Ј-azobisisobutyronitrile) in N,Ndimethylformamide in the presence of a 2,2Ј-bipyridine complex of hexakis(N,N-dimethylformamide)iron(III) perchlorate. The polymerization mechanism was thought to proceed through a reverse atom transfer radical polymerization. The molecular weights of resulting poly(stearyl methacrylate) increased with conversion, and the resulting molecular weight distributions were quite narrow. The rates of polymerization exhibited first-order kinetics with respect to the monomer. A probable reaction mechanism for the polymerization system is postulated to explain the observed results.

In our study, seven most prevailing but unexplored indigenous rice cultivars of northeast India, situated in the Eastern Himalayan Range, were investigated for their phenolic acid profile, total phenolic content (TPC) and antioxidant capacities in free and bound phenolic extracts of their bran. HPLC studies showed the presence of ferulic, p-coumaric, sinapic, caffeic, chlorogenic and vanillic acids, with ferulic and p-coumaric acids being the dominant phenolic acids in the bound form. The lower EC 50 values of the bound extracts than the free extracts suggested the better radical scavenging activity of the bound extracts. Significant correlations were observed between TPC and phenolic acid content (HPLC-DAD) of bound extracts, and between Trolox equivalents antioxidant capacity (TEAC) and phenolic acid content (HPLC-DAD) of both free and bound extracts. The findings suggest that phenolic acids in the rice cultivars investigated were exclusively present in bound form and contribute significantly towards their antioxidant capacity.Free and bound phenolic acids in rice bran A. Begum et al.

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Atom transfer radical polymerization of stearyl methacrylate (SMA) was successfully carried out in N,N-dimethylformamide using the carbon tetrabromide/ Fe(III)/2,2Ј-bipyridine initiator system in the presence of 2,2Ј-azobisisobutyronitrile (AIBN) as the source of the reducing agent to maintain the equilibrium between growing radicals and dormant species. The molecular weights of the resulting poly(stearyl methacrylate) (PSMA) increased with the conversion and the molecular weight distribution of PSMA was quite narrow. The rates of polymerization exhibit first-order kinetics with respect to the monomer. A probable reaction mechanism for the polymerization system was postulated to explain the observed results. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 386 -394, 2002

The versatility of nitroaliphatics is demonstrated by using it in the syntheses of artemisinin derived dimers. A few novel artemisinin derived dimer and monomer have been synthesized using nitroalkane as linker.