Galvanic coupling, or more precisely volume conduction, has been recently studied by different research groups as a method for intrabody communications. However, only in a very few occasions its use for powering implants has been proposed and proper analyses of such capability are still lacking. We present the development and the in vitro validation of a set of analytical expressions able to estimate the maximum ac and dc powers attainable in elongated implants powered by volume conduction. In particular, the expressions do not describe the complete power transfer channel but the behavior of the implants when the presence of an electric field is assumed. The expressions and the in vitro models indicate that time-averaged powers above 1 mW can be readily obtained in very thin (diameter < 1 mm) and short (length < 15 mm) implants when ac fields that comply with safety standards are present in the tissues where the implants are located. The expressions and the in vitro models also indicate that the obtained dc power is maximized by delivering the ac field in the form of short bursts rather than continuously. The study results support the use of volume conduction as a safe option to power implants. INDEX TERMS Conducting materials, implantable biomedical devices, implantable electrodes, wireless power transmission. After working as a Research Engineer with the Translational Research and Knowledge Management Team (Research and Development), Otto Bock GmbH, Duderstadt, Germany, she became a Postdoctoral Fellow at UPF. Her research focuses mainly in exploring and designing miniaturized medical devices for sensing and electrical stimulation.

Aiming at miniaturization, wireless power transfer (WPT) is frequently used in biomedical electronic implants as an alternative to batteries. However, WPT methods in use still require integrating bulky parts within the receiver, thus hindering the development of devices implantable by minimally invasive procedures, particularly when powers above 1 mW are required in deep locations. In this regard, WPT based on volume conduction of high frequency currents is an advantageous alternative relatively unexplored, and never demonstrated in humans. We describe an experimental study in which ac and dc electric powers in the order of milliwatts are obtained from pairs of needle electrodes (diameter = 0.4 mm, separation = 30 mm) inserted into the arms or lower legs of five healthy participants while innocuous and imperceptible high frequency (6.78 MHz) currents are delivered through two textile electrodes strapped around the considered limb. In addition, we demonstrate a procedure to model WPT based on volume conduction which characterizes coupling between the transmitters and the receivers by means of two-port impedance models which are generated from participants' medical images.

Objective. To develop and in vivo demonstrate threadlike wireless implantable neuromuscular microstimulators that are digitally addressable. Approach. These devices perform, through its two electrodes, electronic rectification of innocuous high frequency current bursts delivered by volume conduction via epidermal textile electrodes. By avoiding the need of large components to obtain electrical energy, this approach allows the development of thin devices that can be intramuscularly implanted by minimally invasive procedures such as injection. For compliance with electrical safety standards, this approach requires a minimum distance, in the order of millimeters or a very few centimeters, between the implant electrodes. Additionally, the devices must cause minimal mechanical damage to tissues, avoid dislocation and be adequate for long-term implantation. Considering these requirements, the implants were conceived as tubular and flexible devices with two electrodes at opposite ends and, at the middle section, a hermetic metallic capsule housing the electronics. Main results. The developed implants have a submillimetric diameter (0.97 mm diameter, 35 mm length) and consist of a microcircuit, which contains a single custom-developed integrated circuit, housed within a titanium capsule (0.7 mm diameter, 6.5 mm length), and two platinum-iridium coils that form two electrodes (3 mm length) located at opposite ends of a silicone body. These neuromuscular stimulators are addressable, allowing to establish a network of microstimulators that can be controlled independently. Their operation was demonstrated in an acute study by injecting a few of them in the hind limb of anesthetized rabbits and inducing controlled and independent contractions. Significance. These results show the feasibility of manufacturing threadlike wireless addressable neuromuscular stimulators by using fabrication techniques and materials well established for chronic electronic implants. Although long-term operation still must be demonstrated, the obtained results pave the way to the clinical development of advanced motor neuroprostheses formed by dense networks of such wireless devices.

Sensing implants that can be deployed by catheterization or by injection are preferable over implants requiring invasive surgery. However, present powering methods for active implants and present interrogation methods for passive implants require bulky parts within the implants that hinder the development of such minimally invasive devices. In this article, we propose a novel approach that potentially enables the development of passive sensing systems overcoming the limitations of previous implantable sensing systems in terms of miniaturization. In this approach implants are shaped as threadlike devices suitable for implantation by injection. Their basic structure consists of a thin elongated body with two electrodes at opposite ends and a simple and small circuit made up of a diode, a capacitor and a resistor. The interrogation method to obtain measurements from the implants consists in applying innocuous bursts of high frequency (≥1 MHz) alternating current that reach the implants by volume conduction and in capturing and processing the voltage signals that the implants produce after the bursts. As proof-of-concept, and for illustrating how to put in practice this novel approach, here we describe the development and characterization of a system for measuring the conductivity of tissues surrounding the implant. We also describe the implementation and the in vitro validation of a 0.95 mm-thick, flexible injectable implant made of off-the-shelf components. For conductivities ranging from about 0.2 to 0.8 S/m, when compared to a commercial conductivity meter, the accuracy of the implemented system was about ±10%.

Aiming at miniaturization, wireless power transfer (WPT) is frequently used in biomedical electronic implants as an alternative to batteries. However, WPT methods in use still require integrating bulky parts within the receiver, thus hindering the development of devices implantable by minimally invasive procedures, particularly when powers above 1 mW are required in deep locations. In this regard, WPT based on volume conduction of high frequency currents is an advantageous alternative relatively unexplored, and never demonstrated in humans. We describe an experimental study in which ac and dc electric powers in the order of milliwatts are obtained from pairs of needle electrodes (diameter = 0.4 mm, separation = 30 mm) inserted into the arms or lower legs of five healthy participants while innocuous and imperceptible high frequency (6.78 MHz) currents are delivered through two textile electrodes strapped around the considered limb. In addition, we demonstrate a procedure to model WPT based on volume conduction which characterizes coupling between the transmitters and the receivers by means of two-port impedance models which are generated from participants' medical images.

ObjectiveTo develop and in vivo demonstrate threadlike wireless implantable neuromuscular microstimulators that are digitally addressable.ApproachThese devices perform, through its two electrodes, electronic rectification of innocuous high frequency current bursts delivered by volume conduction via epidermal textile electrodes. By avoiding the need of large components to obtain electrical energy, this approach allows the development of thin devices that can be intramuscularly implanted by minimally invasive procedures such as injection. For compliance with electrical safety standards, this approach requires a minimum distance, in the order of millimeters or a very few centimeters, between the implant electrodes. Additionally, the devices must cause minimal mechanical damage to tissues, avoid dislocation and be adequate for long-term implantation. Considering these requirements, the implants were conceived as tubular and flexible devices with two electrodes at opposite ends and, at the middle section, a hermetic metallic capsule housing the electronics.Main resultsThe developed implants have a submillimetric diameter (0.97 mm diameter, 35 mm length) and consist of a microcircuit, which contains a single custom-developed integrated circuit, housed within a titanium capsule (0.7 mm diameter, 6.5 mm length), and two platinum-iridium coils that form two electrodes (3 mm length) located at opposite ends of a silicone body. These neuromuscular stimulators are addressable, allowing to establish a network of microstimulators that can be controlled independently. Their operation was demonstrated by injecting a few of them in the hind limb of anesthetized rabbits and inducing controlled and independent contractions.SignificanceThese results show the feasibility of manufacturing threadlike wireless addressable neuromuscular stimulators by using fabrication techniques and materials well established for chronic electronic implants. This paves the way to the clinical development of advanced motor neuroprostheses formed by dense networks of such wireless devices.

In situ monitoring of biomedical parameters with implantable sensors can provide information to trigger interventional or therapeutic actions. However, these sensors require bulky components for power or for interrogation that hinder miniaturization. We have proposed a wireless sensing method based in passive rectification of high frequency current bursts that flow through the tissues by volume conduction.Here we report the evaluation of a 0.98 mm-thick, passive, and flexible temperature sensor based on this method. The injectable microsensor obtained an accuracy of ±2.1%. This opens the possibility of continuous and in situ temperature sensing with minimal invasiveness.