The effect of guar gum in capsule form on serum total cholesterol, triglycerides, and lipoprotein cholesterol (very low-density lipoproteins, low-density lipoproteins, and high-density lipoproteins) was studied in healthy volunteers in this double-blind study. Twenty-four subjects equally divided into treatment and placebo groups, received 9.0 g/day of guar and glucose in 600 mg identical capsules, respectively, for 4 wk under conditions of constant body weight and dietary stability. Guar significantly lowered serum total cholesterol (16.6% p less than 0.05) and low-density lipoprotein cholesterol (25.6% p less than 0.05) but had no significant effect (p less than 0.05) on serum triglycerides, high-density lipoproteins and very low-density-lipoprotein cholesterol. No significant changes (p greater than 0.05) were seen in blood lipids in the placebo group.
Background: Hypercholesterolemia and hyperlipidemia are the major problems associated with diabetes. Various agents are being tried to solve these so that problems related to micro-and macroangiopathy can be averted. Plant fibers particularly water-soluble gummy fibers have been reported earlier to reduce blood lipids and cholesterol levels in normal and diabetic animals and humans. Objective: Effects of cholesterol-supplemented and unsupplemented diets containing unextracted and extracted Syzygium cumini seeds on lipid profiles of alloxan-induced diabetic albino rats Material and Methods: Powder of Syzygium cumini seeds was successively extracted using organic solvents, and hypolipidemic and hypocholesterolemic activities of 15% unextracted, 15% extracted, and 15% degummed S. cumini seeds with cholesterol-supplemented and unsupplemented diets were assayed in normal and alloxan-induced diabetic rats. Result: In this study, significant decrease in the levels of total serum cholesterol, serum triglycerides, serum phospholipids, and total cholesterol and triglycerides in tissues of liver, heart, and aorta was observed. Also, significant increase was observed in the phospholipid levels in tissues of liver, heart, aorta, and biliary, and fecal bile acid content and sterols in normal and alloxan-induced diabetic rats. Conclusion: The hypocholesterolemic and hypolipidemic effects of S. cumini seeds may be attributed to their watersoluble gel-forming gummy fiber acting by decreasing cholesterol absorption and breakdown leading to an increased fecal excretion of bile acids and sterols.
In the present study, the effect of feeding of diets containing 12% and 18% water soluble gummy fibre and 5% and 10% water insoluble neutral detergent fibre (NDF) isolated from Syzygium cumini seeds were carried out in normal and alloxan treated diabetic rats for 21 days. The results obtained from present study indicates that incorporation of 12% and 18% water soluble gummy fibre significantly reduces blood glucose, notably improved glucose tolerance and decreased activity of intestinal enzymes i.e. amylase and invertase while 5% and 10 % water insoluble neutral detergent fibre (NDF) did not exhibit any hypoglycaemic effect in both normal and treated diabetic rats.
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