Effect of guar gum on blood lipids

Abstract

The effect of guar gum in capsule form on serum total cholesterol, triglycerides, and lipoprotein cholesterol (very low-density lipoproteins, low-density lipoproteins, and high-density lipoproteins) was studied in healthy volunteers in this double-blind study. Twenty-four subjects equally divided into treatment and placebo groups, received 9.0 g/day of guar and glucose in 600 mg identical capsules, respectively, for 4 wk under conditions of constant body weight and dietary stability. Guar significantly lowered serum total cholesterol (16.6% p less than 0.05) and low-density lipoprotein cholesterol (25.6% p less than 0.05) but had no significant effect (p less than 0.05) on serum triglycerides, high-density lipoproteins and very low-density-lipoprotein cholesterol. No significant changes (p greater than 0.05) were seen in blood lipids in the placebo group.

Effects of Guar-Enriched Pasta in the Treatment of Diabetes and Hyperlipidemia

“…The differences between our findings and those reported by other authors [10, 27,31] may depend both on the selection of patients and on the prescribed dietary treatment. Pa tients selected by us were mostly affected with primary hypertriglyceridemia (with and without hypercholesterolemia); a few had either nephrotic hyperlipidemia or an altered carbohydrate metabolism of the diabetic type.…”

Effect of guar gum on the serum lipid profile of Sprague Dawley rats

“…However, daily consumption of 15 g guar gum considerably reduces serum total cholesterol (Salenius et al, 1995). In another study, 16.6% reduction in total cholesterol was observed by using guar gum in capsule form (Khan, Khan, Mitchel, & Qadeer, 1981). Approximately 40% cholesterol concentration can lowered with daily consumption of 8-36 g guar gum (Gee, Blackburn, & Johnson, 1983;Glore, Treeck, Knehans, & Guild, 1994).…”

“…Intake of 15 g guar gum in the daily diet considerably reduces serum concentration of total and LDL cholesterol without attenuation over 2 years of treatment (Salenius et al, 1995). The effect of guar gum in capsule form significantly lowered 25.6% LDL cholesterol (Khan et al, 1981). In another study, 44% reduction in LDL cholesterol was observed in guinea pigs by feeding soluble fiber diet containing 2.5 g/100g of guar gum, 5 g/100 g of psyllium and 5 g/100 g of pectin diet (Roy et al, 2000).…”

Multifunctional Ingredient Dietary Supplement for Management of Hyperglycemic and Hypercholesterolemic Therapy of Diabetes

“…It was also observed by Sierra et al [31] that consumption of 14 g/d of psyllium in twenty type 2 diabetic patients for 6 weeks resulted in reduction of total and LDL-cholesterol by 7 percent and 9 percent, respectively. Khan et al [32] observed a large reduction (25 percent) in LDL-cholesterol in 24 healthy volunteers receiving 9 g of guar gum per day for 4 weeks. In addition, cocoa powder and dark chocolate also affect cardiovascular disease risk status by modestly reducing LDL oxidation susceptibility, increasing serum total antioxidant capacity and HDL-cholesterol concentrations due to the presence of the flavonoids which have ability to bind with the lipoproteins [33].…”