Introduction: the long term success of root canal treatment is ultimately related to the effective debridement and disinfection of the root canal system. Hence, the irrigants play an important role in achieving the good penetrability and bactericidal activity. The present study was mainly aimed at evaluating the invitro antimicrobial efficacy of Novel Ethanolic Extract of Morinda Citrifolia by agar well diffusion and minimal inhibitory concentration. Materials and Methods:the antimicrobial efficacy of the Novel Ethanolic Extract of Morinda Citrifolia was tested using agar well diffusion and minimal inhibitory concentration was assessed. The zone of inhibitions were determined at 10 mg/ml concentration of Ethanolic Extract of Morinda Citrifolia on agar well plate and Minimal Inhibitory Concentration (MIC) against tested microorganism. Results: results obtained in the present study by both qualitative and quantitative experiments revieled that the tested Ethanolic Extract of Morinda Citrifolia possesses potential antibacterial activity against Enterococcus Feacalis when compared with standard antibiotic tetracycline. the highest zone of inhibition of 15mm was showed at 1000micrograms by agar well diffusion assay. The optimal antimicrobial activity was seen at 250micrograms for Morinda Citrifolia against Enterococcus Feacalis.Conclusion: novel Ethanolic extract of Morinda Citrifolia has shown an optimal antimicrobial activity against E.Feaclais. But still, future studies are still needed.

Background:  Dental caries is challenging infectious disease, which is wide spread and difficult to control. Although it’s multifactorial, microorganisms especially cariogenic Streptococcus mutans plays a wide role in initiation and progression of dental caries. Objective: The present review mainly aimed to evaluate and assess the antibacterial efficacy of herbal versus conventional products on Streptococcus mutans. Data Sources: A search was execute in electronic database (i.e., PUBMEDCENTRAL, COCHRANE, LILAC, SCIENCEDIRECT, GOOGLE SEARCH) using following search terms alone and in combination by means of PUBMED search builder from January 1990 up to July 2019. Study Eligibility Criteria: Studies were stipulate if they met the following criteria: In vivo studies comparing herbal and conventional products on anticariogenic or antibacterial activity on Streptococcus mutans were selected. Participants and Intervention: Adult patients aged from 18-65 years with dental caries undergoing intervention of herbal products. Study Appraisal and Synthesis Material and Methods: Out of 225 studies collected from databases, only 6 studies were included and other 6 were collected by hand search. Finally 12 included studies were analyzed out of which 5 studies were considered for meta-analysis. Results: The results unveil that natural products exerted virtually homogeneous antibacterial effect against Streptococcus mutans when compared with the counterpart. Limitations: Review was assessing on patients with dental caries and studies previously assessed did not mention about the caries risk. Prevalence varies based on caries risk assessments. Study was concentrating only on single species Streptococcus mutans. But ideally caries is multifactorial. Conclusion: Although natural products were effective, the present systematic review does not furnish concrete evidence to a show increased antibacterial efficacy of natural products as compared to conventional products. Keywords Antibiotics, Chlorhexidine, Dental Caries, Herbal, Streptococcus mutans.