atypical ones were noted. On immunohistochemistry, the tumour cells were diffusely positive for CD21, CD23 and vimentin and focally positive for SMA while, were negative for cytokeratin (AE1/ AE3), EMA, p63, CK8/18, PAX-8, S-100, CD68, desmin, CD31, CD30, Alk-1, CD1a, CD20, MUM1, LCA (CD45) and synaptophysin and CD43. Immunohistochemistry with CD21 and CD23 performed on cell block retrospectively also showed diffuse positivity (Figure 2C,D). Based on the histomorphological and immunohistochemical findings, a diagnosis of FDCS was rendered.The smears from the left thyroid showed cytomorphological features consistent with benign follicular nodule. | 465 neoplastic cells intimately admixed with mature lymphocytes is also the tell-tale feature of FDCS on FNA. However, other neoplasms that share this feature are thymoma, lymphoepithelioma-like carcinoma, seminoma, lymphoma, nasopharyngeal carcinoma and medullary carcinoma of breast. Presence of neoplastic cells in syncytial aggregates and singly dispersed, coupled with oval to spindled morphology brings in the differentials of melanoma, gastrointestinal stromal tumour and ectopic meningioma (if they show whorling pattern), but these lack the lymphocytic infiltrate. Another distinctive cytological feature highlighted by few reports is the presence of cytoplasmic processes. 2,8,12,13,15,19,21 Cytoplasmic processes are seen in many tumours, such as nerve sheath tumours, smooth muscle tumours, gastrointestinal stromal tumour and fibrosarcoma, are usually bipolar, while, multipolar interconnecting processes characterise FDCS. 13,15,17,21 However, this feature was lacking in the present case. Cells resembling Reed Sternberg (RS) cells were noted in some reports leading to consideration of lymphoma. 10,17,20 The present case did show multinucleated giant cells but lacked RS cells. The cytological appearance of interdigitating reticulum cell sarcoma and fibroblastic reticular cell tumour are similar to FDCS, thus making it impossible to differentiate. Since cytomorphology alone is often misleading, immunocytochemistry or immunohistochemistry on cell blocks play a crucial role in the diagnosis. Follicular dendritic cell sarcoma cells are typically positive for CD21, CD23, CD35, clusterin, c-synuclein, CXCL13 and podoplanin (D2-40). They also stain for vimentin, EMA, S100 and CD68, which can lead to diagnostic errors if the dendritic cell markers are not performed. They are negative for cytokeratin, CD1a, Lysozyme, MPO, CD34, CD3, CD79a, HMB45, CD34, CD30, HMB-45 and Desmin. 1,24 Aberrant expression of TTF-1, neuroendocrine markers and cytokeratin have also been reported. 25 Recently, two novel, highly sensitive and specific markers for FDCS, Follicular dendritic cell secreted protein and serglycin have been identified. 26 The inflammatory pseudotumour-like FDCS is a distinct variant of FDCS which mimic inflammatory pseudotumour and has a predilection for involvement of intra-abdominal sites. They have spindled tumour cells with a dense lymphoplasmacytic infiltrate in the backg...
Introduction:Ovarian cancer accounts for about 3% of all cancers in women and is one of the leading causes of mortality among all cancers of female genital tract. Incidence rate was 10.2/100,000 females in India in 2013. Study aimed to record the histopathological spectrum of ovarian neoplasms over a period of 1 year in a tertiary care hospital. Material and methods:This retrospective study was done for a period of 1 year (. Here we studied 70 cases of ovarian mass specimen received and fixed in 10%formalin. 4-5micrometer thick sections were cut on microtome and stained by H and E stain for Histopathological Examination Results: In this study, 70 cases of ovarian neoplasms were analysed. Out of these, 68 were primary and 02 were metastatic tumours. Amongst the primary ovarian tumours, 52 were benign, 5 were borderline and 11 were malignant. Histopathologically, surface epithelial tumours were the commonest (36), second most common was germ cell tumour (27) followed by sex cord stromal tumours (5). Benign tumours were common in 21-30 years of age, borderline tumours in 61-70 years of age and malignant tumours in 41-50 years age group. Conclusion:Ovary is a common site of neoplasia in the female genital tract and usually presents with a variety of clinicomorphological and histological features. We have observed an increased incidence of malignancy in our set up because patients usually present in advanced stages of disease, and this is an alarmig finding
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