Histopathological Spectrum pf Ovarian Neoplasms in a Tertiary Care Hospital

Dutta, Aparna; Imran, Reshma; Saikia, Projnan; Borgohain, Mondita

doi:10.21276/ijcmr.2018.5.8.2

Cited by 5 publications

(8 citation statements)

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“…They represent the sixth most common female cancer and the fourth leading cause of death due to cancers in women [2,9] . Repeated ovulatory rupture and repair theoretically creates opportunities for malignant gene mutations and might explain the apparent protective effect of oral contraceptives, late menarche, early menopause, multiparity and breast feeding [10] . Though no age group is free from the tumours, different tumours tend to involve different age groups preferentially.…”

Section: Discussionmentioning

confidence: 99%

“…Though no age group is free from the tumours, different tumours tend to involve different age groups preferentially. The complex anatomy of the ovary and its peculiar physiology with the constant cyclical changes from puberty to menopause give rise to number of cell types which is capable of giving rise to tumours [10] . Nulliparity, family history and genetic mutations are some of the known risk factors associated with the development of ovarian neoplasms.…”

Section: Discussionmentioning

confidence: 99%

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Histomorphological Spectrum of Ovarian Tumours in a Tertiary Care Centre in North India

Sharma¹

2019

jmscr

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Background: Ovarian tumours are a heterogeneous group of neoplasms with variable clinical, morphological and histological features. Malignant epithelial tumours are the commonest ovarian cancers and have high mortality rate. This study was undertaken to analyse histomorphological spectrum of ovarian neoplasm in women of different age groups Aim & Objectives: To evaluate the frequency, distribution and the histomorphological spectrum of various ovarian tumours. Material and Methods: This retrospective study was carried out in the Department of Pathology over a period of three years. All the ovarian tumour specimens received and fixed in 10% formalin formed the study material. 4-5 micrometer thick sections were cut and stained with H&E stain for Histopathological Evaluation.Results: Age range of patients in our study was 21-76 years. Abdominal pain and lump were the commonest presenting symptoms. Majority of the tumours (86.6%) were benign tumours. Malignancy was seen in 9.8 % cases while borderline tumours were seen in 3.6 % cases. Epithelial tumours were the commonest tumours (69.6%) followed by germ cell tumours (25.8%). Serous cystadenoma was the commonest benign tumour and serous cystadenocarcinoma was the commonest malignant ovarian tumour. Conclusions: Ovary is a common site of tumours in the female genital tract and usually presents with a variety of clinicomorphological and histological features. The prognosis and varying therapeutic strategies for ovarian tumours necessitate an accurate pathological evaluation. Newer techniques like IHC have made the diagnosis easier and more precise. However in institutes with limited resources, histopathological study is the gold standard in diagnosis and prognostic evaluation of these tumours.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Histomorphological Spectrum of Ovarian Tumours in a Tertiary Care Centre in North India

Sharma¹

2019

jmscr

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“…Ovarian neoplasms (ONs) comprise 3% of all cancers [ 1 , 2 ], and among female genital tract-related malignancies, the incidence is 25% [ 3 , 4 ]. Ovarian cancer is the fifth most prevalent cancer overall and the second most common gynecological cancer [ 3 , 5 ]. Non-Hispanic whites (11.6 per 100,000) have the highest rate of ONs, followed by the second highest frequency in American Indians and Alaska Natives (10.3 per 100,000), Hispanics (10.1 per 100,000), non-Hispanic blacks, and Asian and Pacific Islanders [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Histopathological Spectrum of Ovarian Neoplasms: A Single-Center Study

Batool¹,

Rathore²,

Jahangir³

et al. 2022

Cureus

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“…An ovarian neoplasm causes mass in the abdomen, pain, and abdominal distension in many cases and hence presents as a silent killer. Due to monthly endocrine and traumatic insults during ovulatory cycles, the ovaries have become susceptible to tumor genesis [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…In 2018, ovarian carcinoma ranked as the eighth most common cancer diagnosed and cause of cancer death in women, with an estimated 295,000 cases and 184,000 deaths worldwide. According to the Global Cancer Observatory (GLOBOCAN) 2018, the age-standardized incidence rate for India is 3.8-5.5 cases per 100,000 females per year [ 2 ], whereas this was 10.2/100,000 females in India in 2013 [ 3 ]. The observed decline was mainly attributed to the use of oral contraceptives, which have long-lasting protective effects against ovarian cancer after several years of use.…”

Section: Introductionmentioning

confidence: 99%

Histomorphological Analysis of Ovarian Neoplasms According to the 2020 WHO Classification of Ovarian Tumors: A Distribution Pattern in a Tertiary Care Center

Mehra¹,

Aditi²,

Prasad³

et al. 2023

Cureus

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Background: In 2018, ovarian carcinoma ranked as the eighth most common cancer diagnosed and the leading cause of cancer death in women. High-grade serous carcinoma is the most common histological type seen among malignant cases. A diverse group of neoplasms is seen in the ovary with variable clinical, morphological, and histological features, so assessing the nature of ovarian neoplasms further assists in the treatment of the disease. Aim: This study was conducted to assess the different histopathological variants of ovarian neoplasms according to the latest 2020 World Health Organization (WHO) classification of ovarian tumors. Further analysis of the frequency, age, clinical features in patients, and distribution of various ovarian tumors is assessed. Materials and methods: A retrospective study was conducted in the Department of Pathology at Patna Medical College and Hospital (PMCH), Patna. The data of the patients from the past three years, from February 2020 to February 2023, were retrieved and assessed. Gross and microscopic findings, including clinical details of patients with ovarian masses, were analyzed from the previous records. Result: A total of 110 cases of ovarian neoplasms on histopathology were analyzed. The age range was 11-70 years. The types of specimens received were those of total abdominal hysterectomy, salphingoopherectomy, and unilateral or bilateral ovarian cystectomy. The most common presentation was an abdominal mass, followed by pain in the abdomen. The majority of the tumors were benign (69%), malignancy was observed in 24.5% of cases, and borderline tumors were seen in 5.4% of cases. Epithelial tumors were the commonest tumors, accounting for 70%, followed by germ cell tumors (21%). Serous cystadenoma was the commonest benign tumor, followed by mature teratoma and serous cystadenocarcinoma. High-grade serous cystadenocarcinoma was the commonest malignant ovarian tumor (9%), followed by low-grade serous cystadenocarcinoma (4.5%) and metastatic carcinoma of the ovary. Krukenberg tumor was seen in two cases, and a very rare case of sclerosing stromal tumor was seen in one of the cases. Conclusion: Ovarian neoplasms usually present with a variety of clinicomorphological and histological features. The most common neoplasm observed in the ovary is surface epithelial tumors, which are benign lesions that commonly affect reproductive age groups. Newer advancements like immunohistochemistry (IHC) and genetic studies have made the diagnosis easier and more precise. However, in institutes with limited resources, a histopathological study is still the gold standard in the diagnosis and prognostic evaluation of these tumors.

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Histopathological Spectrum pf Ovarian Neoplasms in a Tertiary Care Hospital

Cited by 5 publications

References 4 publications

Histomorphological Spectrum of Ovarian Tumours in a Tertiary Care Centre in North India

Histomorphological Spectrum of Ovarian Tumours in a Tertiary Care Centre in North India

Histopathological Spectrum of Ovarian Neoplasms: A Single-Center Study

Histomorphological Analysis of Ovarian Neoplasms According to the 2020 WHO Classification of Ovarian Tumors: A Distribution Pattern in a Tertiary Care Center

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