Since the worldwide emergence of the COVID-19 outbreak, there have been international concerns about the possible viral evolution into variants with underlying mutations that may contribute to their increased transmissibility, disease severity, risk of death, and their potential escape from the immune response or may even lead to its extinction. Rigorous surveillance has revealed the variants harboring mutations in the spike protein, the main target of neutralizing antibodies generated through vaccination or herd immunity. In this review, we have highlighted major SARS-CoV-2 variants as well as other local strains along with their specific mutations, suspected changes in their characteristics, and their impact on the current pandemic and vaccine efficacy. We have also emphasized the need to develop widely protective interventions to curb further transmission of variants.
Improved frequency compensation is proposed for a three-stage amplifier with reduced total capacitance, improved slew rate, and reduced settling time. The proposed compensation uses an auxiliary feedback to increase the total effective compensation capacitance without loading the output node. The proposed compensation scheme is validated in simulation by implementing a three-stage amplifier driving 10 pF load capacitor in a 0.18 μm CMOS process. A detailed comparison of the compensation with a conventional nested Miller compensation is also presented. The simulation results showed a reduction in total compensation capacitance and improvement in slew rate compared to conventional nested Miller compensation and the other reported techniques in the literature.
Autophagy plays a crucial role in cellular development and differentiation as well as in the maintenance of homeostasis in healthy cells. Autophagy is well documented in neurodegenerative disorders, aging, and infectious diseases. However, recognizing its significance in cancer has always been challenging due to its tumor-promoting and suppressive attributes. Various modulators targeting key components of autophagy machinery directly or indirectly have been developed over the years, and have shown promising results in preclinical models. Some of these compounds are even being tested in clinical trials for safety and efficacy. A detailed review of strategies used to target autophagy in cancer is presented including our opinion on developing better therapies and outstanding issues.
A fully-integrated switched-capacitor (SC) DC-DC converter that steps down 2.0 V to 0.9 V with a peak efficiency of 80% is implemented in a 0.18 μ m CMOS process. An ultra-low-power voltage-controlled oscillator that generates a wide range of switching frequencies is proposed to extend battery runtime. An efficiency >70% for load currents in the range of 12 μ A to 17.8 mA is achieved by implementing a novel adaptively-biased pulse frequency modulation (ABPFM) technique in the controller. A symmetric charge-discharge topology with two-phase time interleaving is used as a power stage to reduce the output voltage ripple to <72 mV over the entire load current range.
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