Background
Oritavancin (ORI) is a long-acting lipoglycopeptide indicated for the treatment of adult patients with acute bacterial skin and skin structure infections (ABSSSIs) caused or suspected to be caused by susceptible Gram-positive (GP) pathogens.
Methods
Data collected from a retrospective observational program (2014–2017), Clinical and Historic Registry and Orbactiv Medical Evaluation (CHROME), describe the utilization, outcomes, and adverse events (AEs) associated with ORI in 440 patients treated at 26 US sites for ABSSSI and other GP infections.
Results
Clinical success in evaluable patients receiving at least 1 dose of oritavancin was 88.1% (386/438). In a subgroup of patients who received ORI for skin and soft tissue infections (n = 401) and bacteremia (n = 7), clinical success was achieved in 89.0% and 100%, respectively. A cohort of 32 patients received 2–10 ORI doses separated by no more than 14 days for complicated GP infections. Clinical success was observed in 30 of 32 patients (93.8%), including 10 of 11 (90.9%) patients with bone and joint infections and 7 of 8 (87.5%) patients with osteomyelitis. In the safety evaluable population, the overall rate of AEs was 6.6%.
Conclusions
We describe results from a real-world program that includes the largest multicenter, retrospective, observational study in patients who received at least 1 dose of ORI for the treatment of GP infections. This study confirms that ORI is an effective, well-tolerated antibiotic used in single and multiple doses for the treatment of ABSSSIs and complicated GP infections.
Rates of suicides and attempted suicide are increasing in developing countries and constitute a significant public health problem. A more recent phenomenon is an increase in the rates of attempted suicide and suicide in rural India. The present study was conducted to profile the clinical and demographic characteristics of individuals who presented to a primary health care center with an act of attempted suicide. Most of the attempted suicides were by consumption of organophosphorous compounds. In ma,jority of the cases, the attempted suicides were impulsive in nature and occurred against a background of multiple life stressors operating over a variable period accompanied by significant psychological distress. Very few had sought help from either the informal or formal health sector for psychological distress. Mortality rates among patients with poisoning were high. Enhancing mental health literacy, improving counseling skills of primary care physicians, developing income generating activities and providing better medical facilities at primary care center are an essential component of a comprehensive strategy to combat the increasing rates of attempted suicide in rural India.
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