The remarkable physicochemical properties of gold nanoparticles (AuNPs) have prompted developments in the exploration of biomolecular interactions with AuNP-containing systems, in particular for biomedical applications in diagnostics. These systems show great promise in improving sensitivity, ease of operation and portability. Despite this endeavor, most platforms have yet to reach maturity and make their way into clinics or points of care (POC). Here, we present an overview of emerging and available molecular diagnostics using AuNPs for biomedical sensing that are currently being translated to the clinical setting.

Interaction of AuNPs, AgNPs and MNPs with human serum formed a protein corona.• Methods DDA for the qualitative analysis of the protein coronas.• SWATH-MS for the quantitative analysis of the protein coronas.• The analysis of the protein coronas allowed the identification of novel biomarkers of TNBC.• Role of different protein biomarkers in the diagnosis of TNBC.

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