The C-formylation of 1,3-dimethyl-2(3H)-benzimidazolone and 4-methyl-2H-1,4-benzoxazin-3(4H)-one was performed using 1,1-dichloromethyl methyl ether at the Friedel-Crafts reaction conditions. The formylation of 3-methyl-2(3H)-benzoxa- and -thiazolone at the 6-position was carried out by modified Duff's method with hexamethylenetetramine in trifluoroacetic acid.
Some N-Mannich Bases of 2(3H)-Benzothiazolones and Their Analgesic Activity. -A series of Mannich bases (VI) is synthesized by reaction of benzothiazoles (III) with formaldehyde (V) and the secondary amines ( IV). All compounds are tested for their analgesic activity. -(PETROV, O. I.; ANTONOVA, A. TS.; KALCHEVA, V. B.; DALEVA, L. D.; Med. Chem. Res. 5 (1995) 6, 442-448; Dep. Chem., Sofia Univ., BG-1126 Sofia, Bulg.; EN)
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