Chronic graft-versus-host disease (cGvHD) is an immune mediated late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). Discovery of adequate biomarkers could identify high-risk patients and provide an effective pre-emptive intervention or early modification of therapeutic strategy, thus reducing prevalence and severity of the disease among long-term survivors of alloHSCT. Inflammation, endothelial injury, and endothelial dysfunction are involved in cGvHD development. Altered levels of acute phase reactants have shown a strong correlation with the activity of several immune mediated disorders and are routinely used in clinical practice. Since elevated von Willebrand factor (VWF) and factor VIII (FVIII) levels have been described as acute phase reactants that may indicate endothelial dysfunction and inflammation in different settings, including chronic autoimmune diseases, they could serve as potential candidate biomarkers of cGvHD. In this review we focused on reported data regarding VWF and FVIII as well as other markers of inflammation and endothelial dysfunction, evaluating their potential role in cGvHD.

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Babić et al: B regulatory cells and monocyte subpopulations in chronic graft-versus-host disease www.cmj.hrAim To assess the correlations of B regulatory cells (Bregs) and monocyte subsets in peripheral blood with the National Institutes of Health (NIH)-consensus-defined clinical manifestations of chronic graft-vs-host disease (cGvHD), in an attempt to establish their role as cellular biomarkers.Methods This multidisciplinary prospective study enrolled adult cGVHD patients treated in the

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U članku: Popović N, Mravak Stipetić M, Lelas A, Pulanić D, Radić Krišto D, Aurer I, et al. Prevencija i liječenje mukozitisa u bolesnika sa zloćudnim hematološkim bolestima: pregled područja i stav Hrvatske kooperativne grupe za hematološke bolesti (KROHEM). Medicina Fluminensis. 2021 Dec 1;57(4):373–83. DOI: 10.21860/medflum2021_264893, nepotpuno su navedene afilijacije autora. Ispravno navedene afilijacije autora navedene su ispod:

Mukozitis označava bolnu upalu i oštećenje sluznice usta i gastrointestinalnog trakta koja se javlja kao komplikacija kemoterapijskog i/ili radioterapijskog liječenja i tijekom transplantacije krvotvornih matičnih stanica u bolesnika oboljelih od zloćudnih hematoloških bolesti. Navedeno stanje uvelike utječe na kvalitetu života i ishode liječenja bolesnika. U ovom preglednom radu opisani su čimbenici rizika za pojavu mukozitisa, učestalost, klinička slika, mjere prevencije i liječenja mukozitisa u bolesnika sa zloćudnim hematološkim bolestima te je na temelju aktualne literature i važećih svjetskih smjernica iznesen pregled područja i stav Hrvatske kooperativne grupe za hematološke bolesti (KROHEM).