Scilliroside and other bufadienolide glycosides in red squill, Urginea marítima (L.) Baker, were identified by isolation, high-performance liquid chromatography and thin-layer chromatography. Scilliroside, the major toxic glycoside, occurs in all plant parts including leaves, flower stalk, scales, and especially the roots and core of this bulbous plant. Other scilla compounds detected include desacetylscilliroside, scillarén A, and the aglycon scillirosidin. A new glucosylscilliroside and a phenolic nonscilla glycoside were also isolated and partially characterized. Scilliroside content of bulbs is highest in late summer after a dormancy period and does not appear to change with age. The scilliroside content of seed-derived varieties differs substantially, indicating a genetic factor affecting toxicant levels in the individual seedling plants. Toxicity of the bulbs is due principally to their content of scilliroside. The 6-acetoxy group of scilliroside contributes substantially to this toxicity.
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