Based on data from Indonesian Health Ministry in 2009, osteoporosis case reached 19,7 % of the populations in Indonesia, especially women in menopause period. The treatment was performed by consuming bisphosphonate drugs per oral which was not effective since the absorption intake of the drug was only less than 55% of the intake dosage. Because of that, the bone filler which also has a function as drug delivery system was developed. The hydroxyapatite-gelatin bone filler with the addition of alendronate was studied. To increase the characteristics of this bone filler, glutaraldehyde was introduced in the composite as a crosslinking agent. The concentration of 0.25%, 0.5%, and 0.75% were used. The bone filler was then characterized based on FTIR test, morphology test, compressive strength test, cytotoxicity test, and degradation test. The FTIR result showed that there was no significant difference between the sample with and without glutaraldehyde since the crosslinking bond of glutaraldehyde and gelatin was C=N bond which also presented in the gelatin. The morphology of the samples depicted a bigger pore size for higher glutaraldehyde concentration which also supported by lower compressive strength. All the samples were non-toxic based on the cytotoxicity test which had cell viability more than 100%. The degradation tests showed that with the presence of glutaraldehyde in the bone filler could maintain its form longer than the bone filler without glutaraldehyde. In conclusion, the presence of glutaraldehyde could increase the characteristics of the hydroxyapatite-gelatin composite with the addition of alendronate as a bone filler candidate for osteoporotic bone.
The purpose of this study is to analyze the effect of the Financial Distress toward the Tax Avoidance. To analyze the effect of the Profitability toward the Tax Avoidance. To analyze the effect of the Leverage toward the Tax Avoidance. To analyze the effect of the Sales Growth toward the Tax Avoidance. To analyze the effect of the Good Corporate Governance toward the Tax Avoidance. The sample consist of 34 data of the companies in the healthcare sector listed in Indonesia Stock Exchange for the 2019-2021 period. The data used in this study are secondary data and the method of selecting the sampling using purposive. This research use multiple regression analysis as hypothesis testing. The results showed that Financial Distress have positive significant effect on Tax Avoidance. Profitability have negative significant effect on Tax Avoidance. Leverage have insignificant effect on Tax Avoidance. Sales Growth have insignificant effect on Tax Avoidance. Good Corporate Governance have insignificant effect on Tax Avoidance.
Penelitian ini bertujuan untuk mengetahui hubungan antara psychological capital dengan intensi turnover pada karyawan Matahari Department Store Java Mall Semarang. Psychological capital merupakan kondisi kapasitas dasar individu berupa sifat positif yang dapat membantu individu untuk dapat berkembang. Intensi turnover adalah niat atau keinginan individu untuk meninggalkan pekerjaannya. Penelitian ini dilakukan pada karyawan Matahari Department Store Java Mall wilayah Kota Semarang. Sampel dalam penelitian ini berjumlah 70 orang dengan teknik pengambilan sampel menggunakan convenience sampling. Alat ukur dalam pengambilan data menggunakan skala psychological capital (34 aitem α=0,917) dan skala intensi turvover (27 aitem α=0,914) yang sudah dilakukan uji coba pada 40 orang karyawan. Analisis data yang digunakan dalam penelitian ini adalah analisis regresi sederhana menunjukkan hasil nilai korelasi anntara psychological capital dengan intensi turnover sebesar rxy=0,405, dengan nilai p=0,001 (p<0,05), r2= 0,164, F= 13,318, dan β= -0,405. Hasil analisis menunjukkan bahwa terdapat hubungan negatif yang signifikan antara psychological capital dengan intensi turnover. Hipotesis dalam penelitian ini diterimadengan sumbangan efektif psychological capital sebesar 16,4% pada intensi turnover, kemudian 83,6% lainnya dipengaruhi oleh faktor lain-lain di luar penelitian ini.
Background: Chemical contents in mouthwash could cause several side effects in the oral cavity, hence natural ingredients were used such as Mauli banana stem and basil leaf extract. Mouthwash exposure in the oral cavity affects composite resin, one of it is a bioactive composite resin which has advantages over conventional ones. The contact of mouthwash with bioactive composite resin affects strength properties. Purpose: To analyse the effect of Mauli banana stem and basil extract on the diametral tensile strength value of the bioactive composite resin. Method: Thirty specimens (diameter 6mm x thickness 3mm; n=5/ group) were made using Activa™ Bioactive Restorative (Pulpdent) and immersed in the following group of 25%, 50%, 75% and 100% Mauli banana stem and basil leaf extract as a treatment groups, chlorhexidine gluconate 0,2 % (CHX) and aquadest as a control groups for 24 hours in the incubator at 37oC. Diametral tensile strength value was measured by Universal Testing Machine (Tokyo Testing Machine MFG CO.LTD) with 0,5 mm/minute crosshead speed and 250 kgF load cell. Result: One Way Anova and Post Hoc Bonferroni show there is a significant difference between treatment groups of 25% extract (41,33±6,20 MPa) and treatment groups of 100 % extract (55,06±6,42 MPa). Meanwhile, there is no significant difference for other groups. Conclusion: There is a significant effect of Mauli banana stem and basil leaf extract on the diametral tensile strength value of bioactive composite resin.
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