Long-term use of benzodiazepines (BZDs) is known to induce tolerance and dependence, and increase the risk of falls-related injuries in older adults. We present a study carried out in a French nursing home that concerns the implementation of a BZD withdrawal program reassessed at one year. BZD deprescription was achieved by gradual cessation of doses. A secondary benefit of this program was assessed by comparing the number of falls among residents before and after withdrawal. The number of falls was recorded over a six-month period prior to the onset of withdrawal (T1) and then over a six-month period after reassessment at one year (T2). At the beginning, 31 (28.7%) of the patients were under BZD. Total deprescription was obtained for 11 patients. The number of falls per patient over the T1 period was not different between the two groups (future non-withdrawn and withdrawn patients in BZD): 2.1 ± 1.3 and 2.3 ± 0.6 falls per resident, respectively. Conversely, the number of falls per patient was significantly decreased in the population completely withdrawn in BZD between the T1 and T2 periods (2.3 ± 0.6 vs. 0.5 ± 0.2 falls, p = 0.01). The results show that BZD deprescription, through a gradual reduction of doses, is possible to achieve.
Background: Therapeutic interchange is widely used in geriatric settings, such as angiotensin enzyme converting inhibitors and angiotensin II receptor antagonists and angiotensin receptor blockers (sartans).
[eng] Financial concentration and internationalisation of food industry are the main facts of the eighties. Rationalisation of the working force is another caracteristic of the decade. During this period, financial and economical factors take the lead in the concentration process, overweighting technical factors. On an other hand, the end of the seventies shows a turning point in employment's evolution which had been stable during the thirty pressions years. But these trends in different sectors and countries vary accross countries, according to national specificities and the state of demand satiation. [fre] Les années quatre-vingts ont été marquées par la concentration et l'internationalisation de l'industrie alimentaire européenne. Autre aspect caractéristique de cette décennie : la rationalisation de l'emploi. En effet, pendant les années quatre-vingts, les facteurs économiques et financiers prennent le pas sur ceux d'ordre technique dans la détermination du niveau et des formes de concentration. Par ailleurs, la fin des années 1970 présente un tournant dans l'évolution de l'emploi dans les IAA et qui s'est maintenu pendant trente ans. Cependant, ces deux tendances fortes se manifestent avec des formes diverses dans les différents pays et secteurs en fonction respectivement des spécificités nationales des modèles de développement et des degrés de saturation des marchés.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.