We report on parallel high-resolution electrical single-molecule analysis on a chip-based nanopore microarray. Lipid bilayers of <20 μm diameter containing single alpha-hemolysin pores were formed on arrays of subpicoliter cavities containing individual microelectrodes (microelectrode cavity array, MECA), and ion conductance-based single molecule mass spectrometry was performed on mixtures of poly(ethylene glycol) molecules of different length. We thereby demonstrate the function of the MECA device as a chip-based platform for array-format nanopore recordings with a resolution at least equal to that of established single microbilayer supports. We conclude that devices based on MECAs may enable more widespread analytical use of nanopores by providing the high throughput and ease of operation of a high-density array format while maintaining or exceeding the precision of state-of-the-art microbilayer recordings.
Front Cover: Bio-based epoxy resin with good shape memory properties, in terms of 100% R r , 97% R f , constant thermomechanical cyclic behaviors as well as fast shape recovery speed, were synthesized from renewable isosorbide via thiol-ene coupling reaction in Aqueous Condition. Further details can be found in the article by Talent Exoelectrogens are able to transfer electrons outside the cell to oxidize chemicals anareoebically through extracellular electron transfer mechanisms. This allows them to function in microbial fuel cells. However, there are still limitations and open questions about electron transfer mechanisms and biofi lm-electrode interactions before this technology can be fully implemented in the real world. Back Cover: Amphiphilic triblock copolymers from poly(2-oxazoline)s solubilize huge amounts of the strongly hydrophobic cancer drug paclitaxel. Small-angle neutron scattering revealed a possible reason: Paclitaxel forms small domains which are not only located within the micellar core but also at the interface between the core and the shell of the micelle. Further details can be found in the article by
Abstract. We demonstrate the manufacturing of embedded multimode optical waveguides through linking of polymethylmethacrylate (PMMA) foils and cyclic olefin polymer (COP) filaments based on a lamination process. Since the two polymeric materials cannot be fused together through interdiffusion of polymer chains, we utilize a reactive lamination agent based on PMMA copolymers containing photoreactive 2-acryloyloxyanthraquinone units, which allows the creation of monolithic PMMA-COP substrates through C-H insertion reactions across the interface between the two materials. We elucidate the lamination process and evaluate the chemical link between filament and foils by carrying out extraction tests with a custom-built tensile testing machine. We also show attenuation measurements of the manufactured waveguides for different manufacturing parameters. The lamination process is in particular suited for large-scale and low-cost fabrication of board-level devices with optical waveguides or other micro-optical structures, e.g., optofluidic devices.
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