Background: Children with type 1 diabetes (T1D) are at much higher risk of developing celiac disease (CD) than the general population. The aim of the study was to assess the prevalence and differences in clinical presentation of CD in T1D in different regions of the world. Methods: This study is based on the Better control in Pediatric and Adolescent diabeteS: Working to crEate cEnTers of Reference (SWEET) database. There were 57 375 patients included in the study, aged ≤18 years from 54 SWEET centers. Only centers with screening for celiac disease were included. Regression models adjusted for age, diabetes duration, and gender and a fixed effect in the models for region was used. Diabetes duration, age at diabetes onset, and sex were presented as unadjusted results. Results: CD was present in 2652 subjects (4.5%), with different prevalence among regions: from 1.9% in Asia/Middle East to 6.9% in Australia/New Zealand. CD was observed more often among females. Comparing children with and without CD, characteristics for those with CD were younger age at diabetes onset (6.3 [3.3; 9.8] vs 8.1 [4.6; 11.3], P < 0.001) and had longer diabetes duration (6.4 [3.6; 9.8] vs 4.8 [2.1; 8.2], P < 0.001). Further, they had lower glycosylated hemoglobin (HbA1c) in Europe and North America/Canada; lower body mass index (BMI)-SD score (BMI-SDS) in southern Europe, North America, and Canada; In most regions daily insulin dose was lower, height-SDS was lower, and the percentage of insulin pump users was higher in children with T1D and CD. Conclusions:The prevalence and the anthropometric and metabolic consequences of CD in children with T1D differ around the world.

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Comorbid celiac disease (CD) may affect the course of type 1 diabetes (T1D). We aimed to compare T1D children with and without CD. This study is based on the SWEET (Better control in Pediatric and Adolescent diabeteS:Working to crEate cEnTers of Reference) database. We included 39 425 patients aged ≤18 y. Regression models adjusted for demographics were applied to compare outcomes. CD was present in 1 804 subjects (4.6%). Prevalence of CD differed among regions: 1.9% Asia/Middle East, 4.3% Northern Europe, 5.1% Southern Europe, 5.3% North America/Canada and 6.1% Australia/New Zealand. Girls were diagnosed with CD significantly more often than boys (p&lt; 0.01). Children with CD were younger at diabetes onset (p&lt; 0.001), also when boys and girls were separately analyzed. CD subjects were significantly shorter (p= 0.002) and had lower BMI-SDS (p&lt; 0.001) (Fig). HbA1c was lower in patients with CD (p&lt; 0.001), even after adjustment for pump use (Fig). Across regions, gender differences in CD prevalence were not shown in Northern Europe and Asia/Middle East. HbA1c was lower in CD patients in Southern Europe and North America/Canada. In contrast, in Asia/Middle East, HbA1c was significantly higher among CD patients (p&lt;0.001). No difference was found in Northern Europe. The frequency, anthropometric as well as metabolic consequences of CD in T1D children differs around the world. Disclosure A. Taczanowska: None. A. Schwandt: None. S. Amed: None. J. Svensson: Advisory Panel; Self; Janssen Pharmaceuticals, Inc., Medtronic. Speaker's Bureau; Self; Novo Nordisk A/S, Sanofi-Aventis. Stock/Shareholder; Self; Novo Nordisk A/S. A. Szypowska: None. C. Kanaka-Gantenbein: None. P. Toth-Heyn: None. S. Krepel Volsky: None.

Introduction: This study examined the emotional impact that parents experience when confronted with an increased genetic risk of type 1 diabetes (T1D) in their child. Population-based screening of neonates for genetic risk of chronic disease carries the risk of increased emotional burden for parents.Methods: Information was collected using a well-being questionnaire for parents of infants identified as having an increased risk for T1D in a multinational research study. Parents were asked to complete this questionnaire after they were told their child had an increased risk for T1D (Freder1k-study) and at several time points during an intervention study (POInT-study), where oral insulin was administered daily.Results: Data were collected from 2595 parents of 1371 children across five countries. Panic-related anxiety symptoms were reported by only 4.9% after hearing about their child having an increased risk. Symptoms of depression were limited to 19.4%