Саратовский государственный медицинский университет им. В.И. Разумовского, Российская Федерация В статье представлен случай применения метотрексата для подкожного введения в расчетной дозе 12,5 мг/м 2 поверхности тела в неделю у ребенка с ювенильным идиопатическим артритом. При переключении на парентеральный путь введения метотрексат обеспечил развитие ремиссии суставного синдрома, нормализацию лабораторных показателей активности болезни, улучшение функции суставов. Через 6 мес констатирована с тадия неактивной болезни, через 12 мес-ремиссия. Ключевые слова: ювенильный идиопатический артрит, метотрексат, подкожное введение.
In the article, the authors provide brief information about a rather rare problem of pediatric gastroenterology — bezoars of the gastrointestinal tract. The data on the classifi cation of these pathological formations are presented, the problems of the pathogenesis of the formation of various types of bezoars are briefl y highlighted. Using the example of a clinical case of the detection of two giant bezoars in a teenage girl with high intestinal obstruction, the problem of the complexity of timely diagnosis of this condition in a patient with trichotillomania and trichophagia is discussed. The conclusion is made about the expediency of a comprehensive interdisciplinary approach to this problem in pediatric practice in order to reduce the risks of subsequent severe surgical interventions.
The guide will allow pediatricians to get information about the meaning of eponymous terms that they face in practice, educational and scientific activities, it contains 1212 eponymous symptoms, samples and reflexes, 752 symptom complexes, syndromes and diseases relevant to pediatric practice.
The book consists of two parts, the first part includes the semiotics of pediatric diseases and presents their symptoms and signs. In the second part of the guide are syndromes and nosological units, which are systematized in alphabetical order. Their interpretation, historical information, data on epidemiology, etiology, pathogenesis and clinical picture of nosological units are given. From the standpoint of evidence-based medicine provides information on the diagnosis, treatment and prevention of these conditions, which may occur in the practice of a pediatrician.
The guide is addressed to pediatricians, it is useful to researchers, teachers of higher medical school.
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