This article is devoted to the comorbidity of diseases of the digestive tract and respiratory system in children. Comorbidity (polymorbidity) in the pathology of the gastrointestinal tract is widely described in modern scientific literature, however, the relationship between the digestive and respiratory systems seems to be less studied.The purpose of the study was to analyze the endoscopic signs of refl ux pathology of the digestive tract in children with a comorbid condition — GERD and respiratory diseases occurring with broncho-o bstructive syndrome (BOS).Materials and methods. An in-depth examination of 180 children from 6 to 16 years old with comorbid pathology (respiratory diseases with BOS and GERD) was carried out. Performed: X-ray examination, spirometry, intracavitary pH-metry, EFGDS and ultrasound of the gastrointestinal tract. To study the morphological features of the esophageal mucosa in this comorbidity, biopsies were examined 1 cm above the Z-line; at the same time, a biopsy of the mucosa of the antrum of the prepyloric part of the stomach was performed.Results. Respiratory diseases with biofeedback in the examined groups of patients were most often (43.9%) combined with GERD at the age of 12–14 years. The predominance of endoscopically positive grade 1 GERD is typical for patients with broncho- obstructive syndrome caused by moderate and severe persistent BA, acute and prolonged pneumonia, and recurrent bronchitis. Infl ammatory diseases of the digestive system (chronic gastritis, chronic gastroduodenitis) in BA were detected in 40.6% of patients, in pneumonia — in 45.7%, in recurrent bronchitis — in 33.3% of patients. Based on the data of a general morphological study of biopsy specimens, regardless of age and type of bronchopulmonary pathology, two variants of infl ammation were identifi ed, which are more common than others — with a predominance of dystrophic changes and with a predominance of infl ammation itself, which largely depended on the duration of the disease. In patients suff ering from both BA and pneumonia with biofeedback, morphological changes in the esophageal mucosa corresponded to the catarrhal nature of the infl ammation.
The aim of study is to investigate effectiveness of cross-recurrence analysis for the detection of coupling between the loops of heart rate and vessel tone sympathetic control. The cross-recurrence analysis is applied to the interbeat intervals and photopletysmographic signals from the mathematical model of cardiovascular system and from adults and newborn children. The model is examined under the conditions of the four experiments: with fully operational autonomic control, autonomic control weakened by 40%, autonomic control weakened by 70% and autonomic blockade. The coupling is most pronounced in adult subjects and the model with fully operational autonomic control, while it is absent under the autonomic blockade. Autonomic control is also not fully developed in newborn children. As the result, smaller coupling strength is expected. The results of cross-recurrence analysis of the model and experimental data are compared with the results of coupling detection based on the analysos of phase synchronization. Synchronization index demonstrates good correlation with the coupling strength in the model and weak coupling in newborn children in relation to adult subjects. In both cases, no correlation is observed between the synchronization index and the results of cross-recurrence analysis.
Until now in the information resources data on the reference values of the concentration of this essential trace element in biological fluids in low birth weight (LBW) newborns are absent. The purpose of our study was to study the copper content in serum in various categories of LBW children during the neonatal period. This prospective study included 173 newborns with LBW, including babies with intrauterine growth retardation (IUGR). The dynamic monitoring of copper concentration in the blood serum, as well as the analysis of these parameters depending on the birth weight has been performed. Quantitative determination of serum copper was carried out by the method of emission spectral analysis. When analyzing the level of copper in the blood serum on the 10th and 25th days of life, a lower content of this element was noted in extremely LBW children with (8.10±1.16 and 6.99±0.41, on the 10th and 25th days of life, respectively) and without IUGR (7.49±1.07 and 7.19±0.91, respectively). On the 25th day of life, serum copper levels were reduced in all groups of children (P<0.001). All LBW newborns and especially in children with IUGR has a deficiency of this micronutrient throughout the observation period. In newborns with ELBW or VLBW, there is a deficiency of serum copper throughout the neonatal period.
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