Background. Multiple sclerosis (Ms), the most common cause of non-traumatic disability in adults, is a chronic, complex neurological disease with a variable clinical course and several pathophysiological mechanisms. whole-body cryotherapy (wbc), due to its analgesic effects, is an increasingly popular form of rehabilitation for neurological patients, especially for those with Ms. Objectives. The following study attempted to evaluate the effect of 30 daily whole-body cryotherapy treatments (3 minutes at-130°c) on basic blood biochemical parameters and main antioxidant enzyme activity in the erythrocytes of Ms patients. Material and methods. Total protein, albumin, glucose and uric acid levels and lipid profile indicators: total cholesterol (Tch), HDL cholesterol and triacylglycerol (TAG) concentrations, were determined with the enzymatic colorimetric method. The activity of erythrocyte antioxidant enzymes: soD1/cuzn-soD (superoxide dismutase), cAT (catalase), GPx (glutathione peroxidase), R-GssG (glutathione reductase), GsT (glutathione transferase), was assessed using kinetic methods before and after 30 daily wbc treatment in 30 patients. Results. Following a series of 30 wbc treatments, no significant changes in total protein, albumin, uric acid and glucose concentrations, total cholesterol and HDL-and LDL-fraction cholesterol levels and triacylglycerol concentration, as well as a significant increase in soD1 activity coupled with a trend for increased GsT activity, were observed in the group of patients. Conclusions. The results confirm the possibility of modulating the effect of this form of rehabilitation on the systemic antioxidant potential in multiple sclerosis patients.
Wstęp: Satysfakcję pacjenta coraz częściej rozpatruje się jako ważny element w pomiarze jakości świadczeń oferowanych przez podstawową opiekę zdrowotną (POZ). Celem pracy było określenie poziomu satysfakcji pacjentów z usług POZ.Materiał i metody: Przebadano 124 osoby, korzystając ze standaryzowanego kwestionariusza EUROPEP, opracowanego przez Europejską Grupę Roboczą ds. Jakości w Medycynie Rodzinnej.Wyniki: Doświadczenia 68% badanych wskazują na życzliwość i pomoc pielęgniarek POZ, a ponad połowa respondentów (52%) przypisała te cechy również recepcjonistkom. Większość badanych miała pozytywne zdanie na temat zachowania lekarzy POZ, podkreślając ich delikatność podczas badania (83%), szacunek dla intymności (82%), a także życzliwy stosunek wobec pacjentów (77%). Jednak mimo pozytywnej oceny zachowania, lekarze 52% respondentów nie zaproponowali żadnych badań profilaktycznych, a także w wielu przypadkach (43%) nie przekazali informacji dotyczących zasad zdrowego trybu życia. Co trzeci pacjent (32%) nie otrzymał od lekarza informacji o skutkach ubocznych stosowanych leków. Według wyników badań znacznie mniej niż połowa lekarzy POZ interesuje się sferą psychospołeczną swoich pacjentów. Zaledwie 27% badanych otrzymało ze strony lekarza pomoc w zakresie radzenia sobie z lękami dotyczącymi stanu zdrowia. Jeszcze mniej respondentów doświadczyło zainteresowania lekarza w zakresie ich sytuacji osobistej (23%) bądź materialnej (23%), natomiast pytania dotyczące członków rodziny padły ze strony lekarzy w stosunku do 35% pacjentów.Wnioski: 1. Ogólny poziom satysfakcji pacjentów z usług POZ jest wysoki. Pozytywnie oceniana jest dostępność do lekarza, życzliwość, zainteresowanie problemami zdrowotnymi podopiecznych. 2. Pacjenci POZ odczuwają deficyt działań profilaktycznych i promujących zdrowie, a także uważają za niewystarczające zainteresowanie lekarza problemami psychospołecznymi. 3. Konieczne jest większe zaangażowanie personelu POZ w promocję zdrowia i edukację prozdrowotną. Wskazane są szkolenia z zakresu komunikacji interpersonalnej personelu POZ. 4. Rosnąca świadomość zdrowotna społeczeństwa powoduje większe oczekiwania pacjentów odnośnie informacji o stanie zdrowia i planowanym leczeniu
Multiple sclerosis (MS) is a chronic inflammatory disease of autoimmune origin for which there is currently no available cure. In the course of MS, next to neurological disorders, patients often present with chronic fatigue syndrome and depressive disorders, which impact on their daily function and quality of life. The aim of study was to analyse the relationship between serum parameters of iron metabolism and the severity of fatigue, depressive symptoms, and quality of life in MS patients. Methods: The study sample consisted of 90 people with a diagnosis of multiple sclerosis, age range 19–67 years, whose functional status evaluated using the Expanded Disability Status Scale in 90% of the participants did not exceed 3.5 points. Venous blood samples were collected for blood cell count determination and for the purposes of obtaining serum analysed for the concentrations of iron, ferritin, transferrin, transferrin saturation, unsaturated iron binding capacity (UIBC), and total iron binding capacity (TIBC). The participants were also evaluated according to the Fatigue Severity Scale, Beck Depression Inventory, and Functional Assessment of Multiple Sclerosis. Results: Ferritin levels were significantly correlated with the severity of depressive symptoms (r = −0.22; p = 0.04) and quality of life assessment (r = 0.22; p = 0.04) in the MS patients. Moreover, the severity of fatigue and depressive symptoms was significantly linked to a deterioration in quality of life. Conclusions: Ferritin deficiency in MS patients is associated with an exacerbation of depressive disorders and a decline in quality of life. Symptoms of fatigue in MS patients are inversely proportional to mood and quality of life.
BACKGROUND: The available literature lacks data about the influence of whole body cryotherapy (WBC) on muscle activity in patients with sclerosis multiplex (MS). OBJECTIVE: Assessment of the influence of the 20 WBC series on the surface electromyography (sEMG) signal and the relationship between it and the functional state in patients with MS. METHODS: The study group was 114 of MS patients (aged 45.24±11.88yr.,) which 74 of them received 20 of WBC. An assessment was made of: the hand grip (HGS), Timed 25-Foot Walk, Fatigue Severity Scale, sEMG signal from the dominant limb. RESULTS: After a series of 20 WBC: in the rest electromyograms, an increase of extensor carpi radialis (ECR) and a decrease of flexor carpi radialis (FCR) amplitude were demonstrated (non-normalized signal ECR p = 0.0001); significant differences in sEMG rest signals between ECR and FCR have decreased; for voluntary contraction in both assessed antagonistic muscle amplitude was significantly decreased (p = 0.0005; p = 0.0316, p = 0.0185); an increase of HGS (p < 0.001); gait improvement (p = 0.001); decrease fatigue (p = 0.024). No significant changes were observed in the control group. CONCLUSIONS: Series of 20 WBC improves the functional state and reduces fatigue in patients with MS, which may be due to adaptive changes in bioelectrical muscle activity.
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system in which there is a multifocal damage to the nerve tissue. Additionally, the literature emphasizes the excessive accumulation of iron in the central nervous system of patients, which is negatively correlated with their psychophysical fitness. Iron metabolism genes polymorphisms may modulate iron deposition in the body and thus affect the clinical course of MS. We aimed to assess the frequency of HAMP, TFR2, and TF polymorphisms in MS patients and their impact on the clinical course of the disease. The studied polymorphisms were identified by the Real-Time PCR using TaqMan technology. Neurological assessment by means of EDSS scale was conducted. This cross-sectional study included 176 patients, with the mean age of onset of symptoms at 30.6 years. The frequency of alleles of the studied polymorphisms was as follows: (a) HAMP rs10421768: A 75.9% (n = 267), G 24.1% (n = 65), (b) TF rs1049296: C 89.2% (n = 314), T 10.8% (n = 38), (c) TF rs3811647: A 39.8% (n = 140), G 60.2% (n = 212), (d) TFR2 rs7385804: A 59.1% (n = 59.1%), C 40.9% (n = 144). In the codominant inheritance model of TF rs1049269, it was shown that people with the CT genotype scored statistically significantly lower points in the EDSS scale at the time of diagnosis than those with the CC genotype (CC Me = 1.5, CT Me = 1.0 p = 0.0236). In the recessive model of TF inheritance rs3811647, it was noticed that the primary relapses were significantly more frequent in patients with at least one G allele compared with those with the AA genotype (AG + GG = 81.2%, AA = 18.8%, p = 0.0354). In the overdominant model rs7385804 TFR2, it was shown that among patients with the AA genotype, multiple sclerosis occurs significantly more often in relatives in a straight line compared with people with the AC and CC genotypes (AA = 100.0%, AC + CC = 0.0%, p = 0.0437). We concluded that the studied polymorphisms might affect the clinical course of MS.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.