Bacterial meningitis is still life-treating disease, which cause about 1.2 million cases and it is responsible for over 100 thousand of deaths across the globe. [2][ The most common pathogens which case the disease are Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae and Listeria monocytogenes. Morbidity is significantly higher in Africa, than in other regions in the world. Region of the highest frequency of new cases is located in sub-Saharan Africa and called meningitis belt. Vaccination campaigns against bacterial, mostly meningococcal were conducted in some of these regions and the benefits of it were seen [5]. Young children and elderly patients are predisposed to have bacterial meningitis. In pediatric population the disease usually presents as fever, seizures, vomiting, chills, altered mental status and stiff neck. [4] Development of each country have impact on mortality and morbidity among children. [6] Elderly patients, because of their comorbidity are also predisposed to bacterial meningitis. Diseases like diabetes mellitus, alcoholism, cancer, HIV/AIDS or being after splenectomy may make the patients susceptible for bacterial invasion of CNS. Also, every factor which interrupt blood-brain barrier, like trauma or surgery may cause the infection. Intracerebral hemorrhage can be consequence of the infection, which cause other complications like impaired consciousness, focal neurological deficit, need of mechanical ventilation and seizures. It was noticed that in most of cases bacterial meningitis had S.pneumoniae etiology.
Energy drinks are very popular nowadays. The number of people consuming this type of drink is growing every year, not only in the adult group but also in the population of adolescents and children. For many people, they are an alternative to stimulating coffee. In addition to the desired effects such as reducing fatigue, improving concentration and increasing physical and mental performance, energy drinks can also have adverse effects. The substances they contain, such as caffeine, taurine and large amounts of carbohydrates, may contribute to an increased risk of cardiovascular complications, metabolic and gastroenterological diseases, and mental disorders. [1] The aim of the article is to present the negative effects of consuming energy drinks in the population of adolescents and children.
Coffee is one of the most consumed beverages among adults. Popular for its stimulant properties, it is also appreciated for its taste and is an essential part of many people's daily lives. Coffee, in addition to caffeine, contains macroelements such as sodium, potassium and magnesium, which ensure the proper functioning of the body, as well as polyphenols which are characterised by their anti-inflammatory properties. [1,2] Atrial fibrillation is the most common arrhythmia and caffeine is often considered a potential risk factor. [3] The purpose of this article is to evaluate current scientific reports on the relationship between coffee consumption and atrial fibrillation.
Introduction Pregnancy increases the risk of acute ischemic stroke (AIS) among young women and is responsible for about 5% of maternal deaths and significant disability. Concerns of potential adverse events of imaging and reperfusion therapies in this group of patients can lead to a substantial delay or omission of treatment that can significantly worsen outcomes. Objective The objective of this study is to discuss main concerns of diagnosis and therapy of pregnant patients with AIS regarding neuroimaging and reperfusion treatment. Results The cumulative radiation dose of computed tomography (CT)-based entire diagnostic procedure (noncontrast CT, CT-angiography and CT-perfusion) is estimated to be below threshold for serious fetal radiation exposure adverse events. Similarly, magnetic resonance imaging(MRI)-based imaging is thought to be safe as long as gadolinium contrast media are avoided. The added risk of intravenous thrombolysis (IVT) and mechanical thrombectomy during pregnancy is thought to be very low. Nevertheless, some additional safety measures should be utilized to reduce the risk of radiation, contrast media and hypotension exposure during diagnostic procedures or reperfusion treatment. Conclusion Fetal safety concerns should not preclude routine diagnostic work-up (except for gadolinium contrast media administration) in childbearing AIS women, including procedures applied in unknown onset and late onset individuals. Due to rather low added risk of serious treatment complications, pregnancy should not be a sole contraindication for neither IVT, nor endovascular treatment.
COVID-19 is one of the biggest challenges to medicine ever. Because of its dissemination in population effective drug to cure it was needed. There were some trials on antiviral drugs like lopiravir/ritonavir, remdesivir, darunavir/cobicistat, favipiravir, molnupiravir, discovered originally in order to treat other diseases. Only remdesivir and molnupiravir seem to be beneficial for patients with COVID-19, both of them are approved in therapy in a large number of countries allover the world. [2] Another very important group of drugs used in trials against COVID-19 was immunomodulatory drugs. Some of them, like chloroquine/hydrochloroquine was very promising, but finally there were no evidences of its benefits found. [2] Corticosteroids used in moderate and severe COVID-19 caused general improvement of clinical status and decreased mortality. Interesting and quite promising may be use of interferons but for now lack of evidences does not allow to make clear statement about its benefits. There are some argumentations for natural methods of COVID-19 treatment. Dietary recommendations, vitamin and microelements supplementation may be helpful in the therapy and in addition may not have any adverse effects. Also, herbal mixtures, developed centuries ago in China found usage during COVID-19 pandemic. After analysis of thousands of cases Traditional Chinese Medicine can be considered as one of the most successful attempt in combating COVID-19. [6]
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