The existence of two kinematically and chemically distinct stellar subpopulations in the Sculptor and Fornax dwarf galaxies offers the opportunity to constrain the density profile of their matter haloes by measuring the mass contained within the wellseparated half-light radii of the two metallicity subpopulations. Walker and Peñarrubia have used this approach to argue that data for these galaxies are consistent with constant-density 'cores' in their inner regions and rule out 'cuspy' Navarro-Frenk-White (NFW) profiles with high statistical significance, particularly in the case of Sculptor. We test the validity of these claims using dwarf galaxies in the APOSTLE (A Project Of Simulating The Local Environment) Λ cold dark matter cosmological hydrodynamic simulations of analogues of the Local Group. These galaxies all have NFW dark matter density profiles and a subset of them develop two distinct metallicity subpopulations reminiscent of Sculptor and Fornax. We apply a method analogous to that of Walker and Peñarrubia to a sample of 50 simulated dwarfs and find that this procedure often leads to a statistically significant detection of a core in the profile when in reality there is a cusp. Although multiple factors contribute to these failures, the main cause is a violation of the assumption of spherical symmetry upon which the mass estimators are based. The stellar populations of the simulated dwarfs tend to be significantly elongated and, in several cases, the two metallicity populations have different asphericity and are misaligned. As a result, a wide range of slopes of the density profile are inferred depending on the angle from which the galaxy is viewed.
We test a non-parametric higher-order Jeans analysis method, GravSphere, on 32 simulated dwarf galaxies comparable to classical Local Group dwarfs like Fornax. The galaxies are selected from the APOSTLE suite of cosmological hydrodynamics simulations with Cold Dark Matter (CDM) and Self-Interacting Dark Matter (SIDM) models, allowing us to investigate cusps and cores in density distributions. We find that, for CDM dwarfs, the recovered enclosed mass profiles have a bias of no more than 10 per cent, with a 50 per cent scatter in the inner regions and a 20 per cent scatter near the half-light radius, consistent with standard mass estimators. The density profiles are also recovered with a bias of no more than 10 per cent and a scatter of 30 per cent in the inner regions. For SIDM dwarfs, the mass and density profiles are recovered within our 95 per cent confidence intervals, but are biased towards cuspy dark matter distributions. This is mainly due to a lack of sufficient constraints from the data. We explore the sources of scatter in the accuracy of the recovered profiles and suggest a χ2 statistic to separate successful models from biased ones. Finally, we show that the uncertainties on the mass profiles obtained with GravSphere are smaller than those for comparable Jeans methods, and that they can be further improved if stronger priors, motivated by cosmological simulations, are placed on the velocity anisotropy. We conclude that GravSphere is a promising Jeans-based approach for modelling dark matter distributions in dwarf galaxies.
We present an updated analysis of the gamma-ray flux from the directions of classical dwarf spheroidal galaxies, deriving new constraints on WIMP dark matter (DM) annihilation using a decade of Fermi-LAT data. Among the major novelties, we infer the dwarfs' J-factors by including new observations without imposing any a priori parametric profile for the DM distribution. While statistically compatible with results obtained from more conventional parameterisations, this procedure reduces the theoretical bias imposed on the data. Furthermore, we retain the full data-driven shape of the J-factors' empirical probability distributions when setting limits on DM, without imposing log-normality as is typically done. In conjunction with the data-driven J-factors, we improve on a new method for estimating the probability distribution function of the astrophysical background at the dwarf position [1], fully profiling over background uncertainties. We show that, for most “classical” dwarfs, the background systematic uncertainty dominates over the uncertainty on their J-factors. {Raw distributions of J- and D-factors (the latter being the analogous of J-factors for decaying DM) are available upon request.}
There is an ongoing debate as to how urea denatures proteins in solution. Using a combination of neutron scattering and computer simulation of a model peptide, KGPGK, it was found that the ionic strength and pH have a significant impact on the urea-peptide interaction. From the work presented here, it appears that urea first and foremost decreases the charge-based interactions in solution, such as the TFA-TFA association, before interacting with the peptide backbone via hydrogen bonds. This gives insight into the pH and salt concentration dependency of urea-caused protein denaturation and might unify direct and indirect theories of urea-induced protein denaturation. The observed differences between MD and neutron and X-ray diffraction data might show that MD, in this particular case, underestimates the influence of charged fluorinated solutes.
We extend the generalized Langevin equation (GLE) method [L. Stella, C. D. Lorenz, and L. Kantorovich, Phys. Rev. B 89, 134303 (2014)] to model a central classical region connected to two realistic thermal baths at two different temperatures. In such nonequilibrium conditions a heat flow is established, via the central system, in between the two baths. The GLE-2B (GLE two baths) scheme permits us to have a realistic description of both the dissipative central system and its surrounding baths. Following the original GLE approach, the extended Langevin dynamics scheme is modified to take into account two sets of auxiliary degrees of freedom corresponding to the mapping of the vibrational properties of each bath. These auxiliary variables are then used to solve the non-Markovian dissipative dynamics of the central region. The resulting algorithm is used to study a model of a short Al nanowire connected to two baths. The results of the simulations using the GLE-2B approach are compared to the results of other simulations that were carried out using standard thermostatting approaches (based on Markovian Langevin and Nosé-Hoover thermostats). We concentrate on the steady-state regime and study the establishment of a local temperature profile within the system. The conditions for obtaining a flat profile or a temperature gradient are examined in detail, in agreement with earlier studies. The results show that the GLE-2B approach is able to treat, within a single scheme, two widely different thermal transport regimes, i.e., ballistic systems, with no temperature gradient, and diffusive systems with a temperature gradient.
The recently discovered object Triangulum II appears to be an ultra faint dwarf spheroidal galaxy which may be one of the most dark matter dominated objects yet known. In this work we try to estimate the potential of this object for studies of the indirect detection of self-annihilating dark matter by obtaining its astrophysical J-factor. We perform a basic estimate of the velocity gradient to look for signs of the halo being tidally disrupted but show that the observed value is statistically compatible with zero velocity gradient. We solve the spherical Jeans equation using Markov Chain Monte Carlo (MCMC) engine GreAT and the Jeans analysis part of the CLUMPY package. We find the results point towards a very large J-factor, appearing to make Triangulum II one of the best targets in the search for dark matter. However we stress that the very small number of line of sight velocities currently available for this object make follow up studies essential.
The atomic scale process by which proteins fold into their functional forms in aqueous solutions is still not well understood. While there is clearly an interplay between the sequence of the protein and the surrounding water solvent that leads to highly specific and reproducible folding in nature, there is still an ongoing debate concerning how water molecules aid in driving the folding process. By using a combination of techniques that provide information at the atomic level-neutron and X-ray diffraction and computer simulations-the mechanism of folding in a series of peptides that only vary with respect to the central side-chain residue has been determined. Specifically, β-turn formation for the KGXGK peptide (where X = P, G, S or L) occurs via a two-step water-driven attraction between specific sites on the peptide backbone. This proposed mechanism suggests that the site-specific hydration of the backbone facilitates the initial stages of protein folding and that this hydration interaction in combination with the presence of proline in the i + 1 position helps to stabilize the folded and intermediate folding state of the peptide in solution, leading to a greater propensity for PG containing sequences to occur in β-turns in proteins.
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