No abstract

In 54 patients with leukaemia a raised incidence of HL-A9 was noted as well as a markedly increased association between this antigen and HL-A2. This occurred most frequently in patients with chronic myeloid leukaemia. As HL-A2 and HL-A9 are both antigens of the first series it has been suggested that the predisposition to develop leukaemia is controlled by a recessive gene closely linked to the first HL-A locus and in a linkage disequilibrium with HL-A2 and HL-A9. 5 patients also showed definite changes between antigens of the same series, whilst others suffered a partial or total loss in antigenicity. Lymphocytes from 145 controls did not behave in this way, though other patients receiving radiotherapy also ‘lost’ antigens. So it was postulated that such changes resulted from the treatment of the disease rather than the disease itself.

Organisation und Bibliotheksarbeit. By TIBOR SÜLE and ELLE BRANTHIN. Berlin: Deutscher Bibliotheksverband, 1977. 308p. DM26.50: This work is a collection of contributions from sociological and management points of view. Süle's introduction (pp9–16), which gives a short summary of each paper, attempts an interim account of work within the library field and work as yet unassimilated. The first part of the volume covers sociological aspects, the second management, as seen in Branthin's essay (ppl27–49).

No abstract

54 out of 112 patients with leukaemia have been shown to produce a lymphocytotoxin in their serum when the number of malignant cells present in the peripheral blood was considerably raised but the normal blood cells were low. This lymphocytotoxin reacts with all normal cells. It is a high molecular weight protein, though not an antibody. Partial purification was achieved by elution from DEAE-52-cellulose at about pH 6.9