Lymphocytotoxins in Leukaemia

Dickson, Ann

doi:10.1136/bmj.4.5834.209

Cited by 5 publications

(7 citation statements)

References 3 publications

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“…The existence of a cytotoxic substance in the serum of certain patients with leukaemia was reported previously [1], and the study of a further 61 patients has confirmed those results. As table I shows, a total of 112 pa tients have now been tested of which 54 showed positive lymphocytotoxic reactions.…”

Section: Incidence and Reactivity Of The Lymphocytotoxinsupporting

confidence: 75%

“…The results of the absorption tests are shown in table II and from these it seems clear that the LCT reacted with granulocytes and erythrocytes as well as lymphocytes. Earlier evidence also suggested a reactivity with platelets [1] though under the conditions of the lymphocytotoxicity test it would not kill leukaemic blast cells.…”

Section: Incidence and Reactivity Of The Lymphocytotoxinmentioning

confidence: 99%

“…In the previous paper [1], a method for inhibition by anti-human IgG or anti-hu man IgM was described. Subsequently this was extended to include anti-human IgA, anti-human IgD and a broad spectrum anti-human immunoglobulin.…”

Section: Immunoglobulin Inhibitionsmentioning

confidence: 99%

“…It has been previously reported [1] that a cytotoxic substance was pre sent in the serum of 15 out of 51 patients with leukaemia. It was detected only before, or early during, cytotoxic treatment or during a relapse, and was called a lymphocytotoxin (LCT) due to its activity upon detection.…”

mentioning

confidence: 99%

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Further Observations on the Incidence and Properties of Lymphocytotoxins in Leukaemia

Dickson¹,

Birchmore²

1977

Acta Haematol

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54 out of 112 patients with leukaemia have been shown to produce a lymphocytotoxin in their serum when the number of malignant cells present in the peripheral blood was considerably raised but the normal blood cells were low. This lymphocytotoxin reacts with all normal cells. It is a high molecular weight protein, though not an antibody. Partial purification was achieved by elution from DEAE-52-cellulose at about pH 6.9

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Section: Incidence and Reactivity Of The Lymphocytotoxinsupporting

confidence: 75%

Section: Incidence and Reactivity Of The Lymphocytotoxinmentioning

confidence: 99%

Section: Immunoglobulin Inhibitionsmentioning

confidence: 99%

mentioning

confidence: 99%

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Further Observations on the Incidence and Properties of Lymphocytotoxins in Leukaemia

Dickson¹,

Birchmore²

1977

Acta Haematol

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“…During a recent investigation in this laboratory of patients with leu kaemia for the presence of lymphocytotoxins in the serum [16] , the pa tients were also typed for HL-A antigens with these theories in mind. An attempt was made to determine whether there were any associations be tween HL-A antigens and leukaemia in this population, and to see wheth er any such associations corroborated one of the earlier reports.…”

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confidence: 99%

A Raised Incidence of HL-A2 plus HL-A9 and other Anomalies of the HL-A Antigens of Patients with Leukaemia

Dickson¹

1975

Acta Haematol

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In 54 patients with leukaemia a raised incidence of HL-A9 was noted as well as a markedly increased association between this antigen and HL-A2. This occurred most frequently in patients with chronic myeloid leukaemia. As HL-A2 and HL-A9 are both antigens of the first series it has been suggested that the predisposition to develop leukaemia is controlled by a recessive gene closely linked to the first HL-A locus and in a linkage disequilibrium with HL-A2 and HL-A9. 5 patients also showed definite changes between antigens of the same series, whilst others suffered a partial or total loss in antigenicity. Lymphocytes from 145 controls did not behave in this way, though other patients receiving radiotherapy also ‘lost’ antigens. So it was postulated that such changes resulted from the treatment of the disease rather than the disease itself.

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Autoinhibition of P.H.A. Response by Chronic-Lymphocytic-Leukæmia Serum

Sugden¹

1974

The Lancet

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Lymphocytotoxins in Leukaemia

Cited by 5 publications

References 3 publications

Further Observations on the Incidence and Properties of Lymphocytotoxins in Leukaemia

Further Observations on the Incidence and Properties of Lymphocytotoxins in Leukaemia

A Raised Incidence of HL-A2 plus HL-A9 and other Anomalies of the HL-A Antigens of Patients with Leukaemia

Autoinhibition of P.H.A. Response by Chronic-Lymphocytic-Leukæmia Serum

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