A quantitative structure-activity relationship study was performed for a number of aroylhydrazine compounds with respect to their biological activity against spruce budworm. It was found that the biological activity can be modulated by substituents on the aromatic rings. Substituents with high .ir value and small L value lead to increase in biological activity. Molecular mechanics calculations were used to explain how the active compounds may mimic the strong-binding Y region of ecdysone.Key words: spruce budworm, ecdysone, agonist, hydrazines, quantitative structure-activity relationship.RCsumC : On a effectuC une Ctude de la relation quantitative structure-activiti d'un certain nombre de composCs aroylhydrazines par rapport 2 leur activitC biologique contre tordeuse d'kpinette. On a trouvC que l'activitt peut Etre modulCe par les substituants attachts au noyaux aromatiques. Les substituants avec des valeurs ClevCes de .ir et des valeurs de L faibles augmentent llactivitC biologique. On a utilisC des calculs de mCcanique molCculaire pour expliquer comment les composts actifs peuvent mimer la rCgion Y de forte liaison de l'ecdysone.
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