“…Recently, nonsteroidal 1,2dibenzoyl-1-tert-butylhydrazine and its congeners (SBH), as a new class of insecticides having totally different structures, were found to mimic the action of 20-HE to activate the ecdysone receptor (Wing et al, 1988a;Spindler-Barth et al, 1991), leading to lethal premature molting (Kubo et al, 1983;Chandler et al, 1992;Darvas et al, 1992); the former was found to be more potent than the latter (Wing et al, 1988b). Some researchers have studied the synthesis and quantitative structureactivity relationship of several substituted 1,2-dibenzoyl-1-tert-butylhydrazines (Oikawa et al, 1994a,b;Mohammed-Ali et al, 1995); it was found that the effects of substituents on activity were a very complicated case, as various effects, e.g. molecular hydrophobicity and steric and electronic factors, seemed to overlap (Oikawa et al, 1994a).…”