Ecdysone Agonists: Mechanism and Biological Activity

Smagghe, Guy; Degheele, Danny

doi:10.1007/978-3-662-03565-8_2

Cited by 10 publications

(5 citation statements)

References 39 publications

(48 reference statements)

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“…Also, spintoram has broad-spectrum insect control and low environmental effect on non-target species (Crouse, 2007). In addition, the diacylhydrazines (as Methoxyfenozoid) are considered highly selective with no harm to natural enemies (Dhadialla et al 1998;Smagghe and Degheele 1998). Hence, they can be considered as important addition to insect pest management programs.…”

Section: Field and Semi-field Studiesmentioning

confidence: 99%

Field evaluation and biochemical studies of novel insecticide on the cotton leafworm, Spodoptera littoralis (Boisd).

Hassan

Khaled

Hussein

et al. 2014

Egyptian Academic Journal of Biological Sciences. A, Entomology

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Field evaluation for the efficacy of indoxacarb, spinetoram and methoxyfenozide against larval instars of S. littoralis, infested clover plants Trifoliuma lexandrium was studied at two different Governorates (Al-Qalyubia and El-Fayoum) during cultivation season 2012-2013.All three insecticides, of indoxacarb, spinetoram and methoxyfenozide had no great difference among themselves in reducing the larval population of S. littoralis with difference in the time needed to induce this reduction according to the mode of action of these insecticides.The initial reductionwas recorded after 1 day from spraying for indoxacarb and spinetoram while after 3 days from spraying for methoxyfenozide. Indoxacarb was the most effective insecticide followed by methoxyfenozide and spinetoram.Under semi-field conditions, results showed that, at Al-Qalyubia Governorate, persistence of indoxacarb is higher than other tested insecticides while, the half life of all tested compounds is short at El-Fayoum Governorate.Tolerance to the toxicity of the three tested insecticides increased as the larvae grew older from 2 nd to 4 th instar.Biochemical clarification was carried out in an attempt to disclose the effect of sub-lethal concentration (LC 50) of the three tested insecticides; on haemolymph contents of 6 th instar larvae of S. littoralis which was treated as 4 th larval instar with LC 50 of the tested insecticides and their effects on main components of insect metabolites and changes in protein patterns.

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Section: Field and Semi-field Studiesmentioning

confidence: 99%

Field evaluation and biochemical studies of novel insecticide on the cotton leafworm, Spodoptera littoralis (Boisd).

Hassan

Khaled

Hussein

et al. 2014

Egyptian Academic Journal of Biological Sciences. A, Entomology

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“…Methoxyfenozide (RH‐2485; Fig 1, 4 ), first announced by Le et al 9 in 1996, is the newest and most efficacious member of the diacylhydrazine class. The mechanistic aspects of methoxyfenozide (and diacylhydrazine) insecticidal activity have already been the subject of reviews 10–12. The present paper will provide a brief updated summary of the chemistry and basic biology of this new insecticide.…”

Section: Introductionmentioning

confidence: 97%

The chemical and biological properties of methoxyfenozide, a new insecticidal ecdysteroid agonist

et al. 2001

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Methoxyfenozide [N-tert-butyl-N'-(3-methoxy-o-toluoyl)-3,5-xylohydrazide; RH-2485] is the newest diacylhydrazine insecticide to reach the marketplace. It binds with very high affinity to the ecdysone receptor complex (EcR:USP) in lepidopteran insects [Kd = 0.5 nM (Plodia)], where it functions as a potent agonist, or mimic, of the insect molting hormone, 20-hydroxyecdysone (20E). Methoxyfenozide exhibits high insecticidal efficacy against a wide range of important caterpillar pests, including many members of the family Pyralidae, Pieridae, Tortricidae and Noctuidae. It is most effective when ingested by the target caterpillar, but it also has some topical and ovicidal properties. It is modestly root systemic, but not significantly leaf-systemic. Evidence collected to date indicates that methoxyfenozide has an excellent margin of safety to non-target organisms, including a wide range of non-target and beneficial insects.

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“…Since the methoxyfenozide mode of action mimics natural ecdysone, the reduction of organism weight could be due to a drop in feeding as a consequence of the activity of the insecticide and the presence of the double cephalic capsule, which interferes with larval feeding. Inhibition of this endpoint was also detected for this and other IGRs on Diatrea grandiosella (Dyar) (Lepidoptera: Crambidae), S. littoralis, and M. unipuncta (Smagghe and Degheele 1998;Gobbi et al 2000;Pineda et al 2007).…”

Section: Invertebrate Reproduction and Development 203mentioning

confidence: 71%

Lethal and sublethal effects of cypermethrin and methoxyfenozide on the larvae ofRachiplusia nu(Guenee) (Lepidoptera: Noctuidae)

Rimoldi

Fogel

Schneider

et al. 2012

Invertebrate Reproduction & Development

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Rachiplusia nu is a defoliator lepidopteran species considered a potential pest in soybean and other crops. Cypermethrin is the main insecticide used in Argentina. Worldwide trends in pest control promote the use of insecticides with high specificity like methoxyfenozide; however, their usage in South America is still incipient. The effectiveness of cypermethrin and methoxyfenozide was studied on fifth larval instar of R. nu under chronic exposure in laboratory conditions. Four dilutions (between 10% and 80%) of the maximum field recommended concentration for each insecticide were assessed. Methoxyfenozide caused 100% larval mortality in all tested concentrations, while at tested cypermethrin concentrations, larval mortalities were between 75% and 98%. Cypermethrin treatments showed higher mean survival time values than methoxyfenozide. Both insecticides inhibited larval growth according to weight loss assessment. Cypermethrin also inhibited diet consumption during the first 24-h exposure.

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Ecdysone Agonists: Mechanism and Biological Activity

Cited by 10 publications

References 39 publications

Field evaluation and biochemical studies of novel insecticide on the cotton leafworm, Spodoptera littoralis (Boisd).

Field evaluation and biochemical studies of novel insecticide on the cotton leafworm, Spodoptera littoralis (Boisd).

The chemical and biological properties of methoxyfenozide, a new insecticidal ecdysteroid agonist

Lethal and sublethal effects of cypermethrin and methoxyfenozide on the larvae ofRachiplusia nu(Guenee) (Lepidoptera: Noctuidae)

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