Background. Diabetic Peripheral Neuropathy (DPN) is one major microvascular complication of long-standing diabetes mellitus with a prevalence of 50-60%. DPN leads to decreased quality of life, increased morbidity, and mortality. C reactive protein (CRP) and adenosine deaminase (ADA) are independent inflammatory markers; the current study aims to evaluate and compare serum ADA, CRP in diabetic patients with and without neuropathy. Methods. A prospective study was done on 160 diabetic patients with and without neuropathy who visited the Medicine Department of Kasturba Hospital Manipal. Patients were grouped into two: diabetics with neuropathy (n = 80) and without neuropathy (n = 80). Serum samples were collected and analyzed for CRP and ADA. Results. The data were analyzed using the independent t-test and Mann-Whitney U test. There was a significantly high level of ADA (P = 0.032) in neuropathy patients when compared with the non-DPN group. No significant difference was seen in CRP levels (P = 0.123) in DPN patients compared to non-DPN patients.
Conclusion. Monitoring of inflammatory markers likeADA in diabetic patients can provide insight into preventing DPN and its associated complications.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.