Vitamin D attenuates biofilm-associated infections via immunomodulation and cathelicidin expression: a narrative review

Benson, Ruby; Unnikrishnan, Mazhuvancherry Kesavan; Kurian, Shilia Jacob; Velladath, Saleena Ummer; Rodrigues, Gabriel; Hariharapura, Raghu Chandrashekar; Muraleedharan, Anju; Venkateshiah, Dinesh Bangalore; Banerjee, Barnini; Mukhopadhyay, Chiranjay; Johnson, Aieshel Serafin; Munisamy, Murali; Rao, Mahadev; Kochikuzhyil, Benson Mathai; Miraj, Sonal Sekhar

doi:10.1080/14787210.2023.2151439

Cited by 4 publications

(1 citation statement)

References 101 publications

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“…Multiple studies have reported direct association of Vitamin D with DFU [11][12][13]. Vitamin D particularly has emerging role as antimicrobial and anti-inflammatory agents via production of antimicrobial peptide, inhibiting bacterial biofilm, and suppress the activation of T-cells [14][15][16]. Despite this, the evidence gained in the preceding investigations is limited.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D supplementation improves foot ulcers among diabetic patients: Pooled analysis of randomized controlled trials

Putra,

Gusti,

Duta

et al. 2023

Narra X

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Serum vitamin D level is associated with the development of diabetic foot ulcer (DFU), and it is intriguing to determine if the vitamin supplementation could reverse the diabetic complication. The aim of this study was to investigate the efficacy of vitamin D supplementation in DFU management through qualitative and quantitative systematic review. A systematic search was conducted to screen the records identified in PubMed, Scopus, Embase, Scillit, Sci-Finder, LILACS, EuropePMC, medRxiv, bioRvix, Google Scholar, Semantic Scholar, and Garuda databases as of 10 March 2023. Studies investigating the efficacy of a single dose supplementation of vitamin D in DFU management were included. Quality of the included studies was appraised by Cochrane ‘Risk of Bias’ 2.0. Random-effects-based pooled analysis using Cohen’s d was performed on the wound healing progress as the primary outcome. A sensitivity test with leave-one-out method and meta-regression were also conducted to analyze the effect of heterogenous data. Five studies with a total of 245 patients (123 versus 122 for experimental and control groups, respectively) were finally included in the qualitative and quantitative analysis. The pooled estimate suggested that administering vitamin D to DFU patients could reduce the wound area or depth significantly as compared to control group (p<0.001; Cohen’s d: 2.72; 95% CI: 1.02 to 4.42). The value remained positive throughout the leave-one-out analysis. Vitamin D supplementation significantly contributed to the increased level of serum vitamin D (p=0.026, Cohen’s d: -0.719; 95% CI: -1.35 to -0.09). Elevation of high-density lipoprotein was observed in pooled estimate with p=0.016 and Cohen’d: 1.34 (95% CI: 0.25 to 2.44). Qualitatively, significant reduction of HbA1C, total cholesterol, and C-reactive protein were reported in at least two trials. Significantly improved quantitative insulin sensitivity check index (QUICKI) and decreased malondialdehyde, fructosamine, and fasting blood glucose were reported in at least one trial each. There were conflicting results on the change of low-density lipoprotein level. This study highlights that vitamin D supplementation promotes wound healing process among DFU patients; however, it is too premature to draw solid conclusions as the efficacy could be affected by multiple factors. Therefore, clinical trials from various demographics and ethnicities by using a high- versus low-dose model are needed.

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Section: Introductionmentioning

confidence: 99%

Vitamin D supplementation improves foot ulcers among diabetic patients: Pooled analysis of randomized controlled trials

Putra,

Gusti,

Duta

et al. 2023

Narra X

View full text Add to dashboard Cite

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1,25 dihydroxyvitamin D3-mediated effects on bovine innate immunity and on biofilm-forming Staphylococcus spp. isolated from cattle with mastitis

Tiraboschi,

Isaac,

Breser

et al. 2024

The Journal of Steroid Biochemistry and Molecular Biology

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The role of cathelicidins in neutrophil biology

Yoon,

Puentes,

Tran

et al. 2024

Journal of Leukocyte Biology

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Despite their relatively short lifespan, neutrophils are tasked with counteracting pathogens through various functions, including phagocytosis, production of reactive oxygen species (ROS), neutrophil extracellular traps (NETs), and host defence peptides. Regarding the latter, small cationic cathelicidins present a conundrum in neutrophil function. Although primarily recognized as microbicides with an ability to provoke pores in microbial cell walls, the ability of cathelicidin to modulate key neutrophil functions is also of great importance, including the release of chemo-attractants, cytokines and ROS, plus prolonging neutrophil lifespan. Cumulative evidence indicates a less recognized role of cathelicidin as an “immunomodulator;” however, this term is not always explicit and its relevance in neutrophil responses during infection and inflammation is seldom discussed. This review compiles and discusses studies of how neutrophils use cathelicidin to respond to infections, while also acknowledging immunomodulatory aspects of cathelicidin through potential crosstalk between sources of the peptide.

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Vitamin D attenuates biofilm-associated infections via immunomodulation and cathelicidin expression: a narrative review

Cited by 4 publications

References 101 publications

Vitamin D supplementation improves foot ulcers among diabetic patients: Pooled analysis of randomized controlled trials

Vitamin D supplementation improves foot ulcers among diabetic patients: Pooled analysis of randomized controlled trials

1,25 dihydroxyvitamin D3-mediated effects on bovine innate immunity and on biofilm-forming Staphylococcus spp. isolated from cattle with mastitis

The role of cathelicidins in neutrophil biology

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