Background. Metformin is the first-line oral antidiabetic agent used in the treatment of diabetes mellitus. One of the adverse reactions of the long term use of metformin is cobalamin malabsorption. Clinical and laboratory findings are important in the diagnosis of cobalamin deficiency.Objective. This study aimed to evaluate the risk of cobalamin deficiency symptoms related to long-term use of metformin in type 2 diabetes mellitus patients at Pasar Rebo General Hospital in Jakarta.Setting. This quantitative, observational study with retrospective cohort design was conducted in outpatient department Pasar Rebo General Hospital November 2015 until January 2016.Methods. 200 subjects were recruited and divided into two groups, patients who had been taking metformin for 1-3 years and patients who had been taking metformin for more than 3 years. Each patient was assessed for the presence of cobalamin deficiency symptoms.Main outcome measure. Cobalamin deficiency symptoms evaluated were symptoms of neuropathy (measured by DN4 questionnaire) and hematologic abnormalities associated to cobalamin deficiency, i.e. macrocytic erythrocyte, hypersegmented neutrophils, and giant bands.Results. There are significant differences in the proportions of neuropathy symptoms (RR 2.36, 95%, p=0.000) and hematologic abnormalities (RR 1.5, 95%, p=0.007) between the two groups.Conclusions. Long-term use of metformin (≥3 years) may increase the risk of cobalamin deficiency symptoms in type 2 diabetes mellitus patients.
Latar Belakang: Salah satu penyebab kematian nomor satu di dunia setiap tahun dan faktor risiko ketiga kematian dini adalah hipertensi. Pengobatan untuk hipertensi dapat diberikan melalui terapi non farmakologi salah satunya yaitu dengan terapi akupresur. Tujuan dari literature review untuk mengetahui pengaruh terapi akupresur terhadap tekanan darah pada pasien dengan hipertensi. Metode: Study ini menggunakan literature review dengan metode pencarian artikel menggunakan PICOTT question pada database Trip, PubMed, dan Google Scholar. Penelusuran dibatasi pada artikel teks lengkap, penelitian asli, jurnal nasional dan internasional, yang diterbitkan pada tahun 2015-2020. Ditemukan 84 artikel dari semua basis data, 63 artikel Google scholar, 17 artikel PubMed, 4 artikel Trip. Hasil: Peneliti menemukan 10 artikel yang sesuai dengan kriteria inklusi dan eksklusi. Hasil literature review menunjukkan hasil dari setiap artikel yaitu terdapat pengaruh terapi akupresur terhadap tekanan darah pasien dengan hipertensi di dalam 8 artikel, sedangkan ada 2 artikel yang tidak ada pengaruh terapi akupresur terhadap tekanan darah pasien dengan hipertensi. Kesimpulan: Terapi akupresur sebagai salah satu terapi komplementer diharapkan mampu untuk diaplikasikan perawat dalam menurunkan tekanan darah pada penderita hipertensi.
Diabetes Mellitus is a group of metabolic diseases with characteristic hyperglycemia that accurs due to abnormalities in insulin secretion, insulin action or both disorders. Management of Diabetes Mellitus one of which is the bean stew. Bean stew contain substances stigmasterol and sitisterol that can stimulate the pancreatic β- cells to secrete insulin in peripheral tissues. The purpose of this study was to determine the influence of bean stew on blood sugar levels in people with DM .The research method used experimental research design that is one group pre test-post test design, which reveal a causal relationship by engaging a group of subjects were observed prior to treatment. Samples taken by 32 respondents. The resulting data were analyzed using the Wilcoxon test with 0,05 significance level.The results showed that there was a bean stew effect on blood sugar levels. In the experimental group before the treated bean stew almost 100% had hyperglycemia number of 32 respondents. Then after being given treatment hampit 100% decrease, slthough not within normal limits number of 32 respondents. After calculation by Wilcoxon test was obtained count value (4,89) table (1,96), then the alternative hypothesis is accepted and the null hypothesis is rejected, it means there chickpea stew influence on blood sugar levels in people with DM.Bean stew can lower blood sugar levels in DM patients. Expected DM patients experiencing hyperglycemia can use in addition to pharmacological therapies that bean stew in addressing the problem of blood sugar levels.
A phenomenon that often occurs in human resource management systems in several companies is turnover intention. Turnover Intention is one of the critical issues that is often studied by many researchers in organizational studies from various perspectives. This study's purpose was to partially and jointly determine the effect of work-life balance and job satisfaction on the turnover intention of contract employees in the textile industry in Kudus, Central Java. Contract employees are believed to be the group most at risk of high turnover intention in the organization. The data used are descriptive analysis and explanatory analysis using a sample of 105 questionnaires from 117 questionnaires that have been distributed to selected groups using the census sampling method. 3 Hypothesis testing using SPSS for windows version 25. The significance test (T-test & F-test) shows that work-life balance and job satisfaction have a negative and significant relationship partially and simultaneously on the desire to move on contract employees of PT. Sukuntex –Spinning Kudus. The findings of this study detect that the work satisfaction variable is the element that most influences the level of desire to change jobs among contract employees of PT. Sukuntex – Spinning Kudus.Fenomena yang sering terjadi pada sistem manajemen sumber daya manusia di beberapa perusahaan adalah turnover intention. Turnover Intention adalah salah satu isu kritis yang sering dipelajari oleh banyak peneliti dalam studi organisasi dari berbagai perspektif. Tujuan penelitian ini untuk mengetahui pengaruh work-life balance dan kepuasan kerja secara parsial dan simultan terhadap turnover intention karyawan kontrak pada industri tekstil di Kudus, Jawa Tengah. Karyawan kontrak diyakini sebagai kelompok yang paling berisiko memiliki keinginan berpindah yang tinggi dalam organisasi. Data yang digunakan adalah analisis deskriptif dan analisis eksplanatori dengan menggunakan sampel sebanyak 105 kuesioner dari 117 kuesioner yang telah dibagikan kepada kelompok terpilih dengan menggunakan metode senus sampling. 3 Hipotesis diuji menggunakan SPSS for windows versi 25. Berdasarkan hasil penelitian uji signifikansi (Uji T & Uji F) menunjukkan bahwa work-life balance dan kepuasan kerja memiliki hubungan yang negative dan signifikan secara parsial dan simultan terhadap keinginan berpindah pada karyawan kontrak PT. Sukuntex – Spinning Kudus. Temuan penelitisn ini mendeteksi bahwa variabel work satisfaction merupakan elemen yang paling mempengaruhi tingkat keinginan untuk berpindah kerja di antara karyawan kontrak PT. Sukuntex – Spinning Kudus.
Background: Education is one of the important sectors in development of every country. According to Indonesian Law Number 12, 2012 Education is a conscious and planned effort to develop all the potential of students through the learning process. To see the level of achievement of educational goals, a form of evaluation is needed. Anxiety is an unpleasant feeling of fear accompanied by increased physiological tension, where there is an impulse between threatening situations but must be faced or avoided. Coping mechanisms are mechanisms that individuals use to deal with accepted changes. Individual coping abilities depend on temperament, perception, and cognition as well as the background/cultural norms in which they grew up. The purpose of this study to determine the correlation between anxiety levels and coping mechanism in facing examination at SMAN 1 Giri in 2022. Methods: This study used a cross-sectional design with a purposive sampling and 172 respondents were taken as a sample. Collecting data using Hamilton Anxiety Rating Scale (HARS) and Brief Cope questionnaire then analyzed using the Chy-Square Test with SPSS 25 for windows 10. Results: Most of responden female 119 respondent (69%) and male 53 respondent (31%), most of responden (48%) were in the moderate axiety levels and some of them (51%) were in mechanism coping maladaptive. Based on the analysis results obtained a significant study (2- tailed) 0.002<0.005, which means there is a the correlation between anxiety levels and coping mechanism in facing examination at sman 1 giri in 2022. Conclusion: Coping mechanisms are very important for students to be able to reduce the anxiety they feel besides support from family, friends also play an important role in reducing anxiety in students who have anxiety disorders.
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