This study evaluated the chemical composition and anti-proliferative activity of essential oils (EOs) obtained by hydrodistillation from seven medicinal plants from Cachicadán, La Libertad Region, Peru. Limonene (0.64 to 44.43%) and linalool (0.36 to 2.12%) were identified in all EOs by gas chromatography coupled to mass spectrometry analysis. The major components (relative intensity ≥ 10%) were cisdihydro carvone, carvone, and cis-piperitone epoxide for Minthostachys mollis leaves; β-pinene, limonene, and ledol for Lepechinia heteromorpha leaves; limonene, neral, and geranial for Aloysia citriodora, both leaves and flowers; αpinene, and limonene for Myrcianthes myrsinoides leaves; and α-pinene, βmyrcene, and (E)-β-Ocimene for Dalea carthagenensis leaves. Constituted by (Z)β-ocimene, dihydrotagetone, (Z)-tagetone, and car-3-en-2-one, EO of Tagetes minuta leaves induced an irreversible cytostatic effect against MCF-7 human breast tumour cells. Further in vivo studies must be carried out to establish the safe and efficient dose of T. minuta EO as adjuvant treatment in oncological therapies.
The baru (Dipteryx alata Vogel) is a fruit of the Brazilian Cerrado, composed of a pleasant-tasting almond with a high oil content. The consumption of vegetable oils is suggested by the World Health Organization, but vegetable oils lack protection when extracted from their food matrix. Thus, the hydrocolloids Arabic gum (AG) and maltodextrin (MD) as well as the partially defatted cake (PDC), a co-product of the baru cold-pressed oil, were used to produce baru oil microparticles by spray drying. Fatty acid profile, emulsion stability, microparticle quality, and oxidative stability were evaluated. Baru oil is rich in omega-9 (47.3%). AG/MD (25% maltodextrin) showed better emulsion stability after 1h of preparation, higher zeta potential (-28.87 mV ± 0.026) and encapsulation efficiency (76.72% ± 0.002), and lower peroxide content after 4 weeks at 60°C (28.38 meq/kg). The addition of PDC improved the efficiency parameters in relation to the standard formulation (AG). The replacement of 25% of AG by MD improved the emulsion and microparticles' characteristics and better protected the baru oil against oxidation. Through a well-known technique, this study found technological use for a co-product of the extraction of baru oil and made good use of maltodextrin, a hydrocolloid with a lower relative cost.
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